(E)-N-(1-acetyl-2,3-dihydroindol-5-yl)-3-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-N-(1-acetyl-2,3-dihydroindol-5-yl)-3-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide
• 化学式: C₃₂H₃₅N₃O₂
• 分子量: 493.6
• InChiKey: OVOXKDFJBLROBN-NTCAYCPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  43.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Administration of 4-aminopiperidine compounds for inducing and/or stimulating the growth of keratin fibers and/or preventing loss thereof
  申请人：Cavezza Alexandre

  公开号：US20070253924A1

  公开（公告）日：2007-11-01

  Agents for inducing and/or stimulating the growth of human keratin fibers and/or preventing their loss and/or increasing their density include at least one 4-aminopiperidine compound of formula (I): in which: Alk 1 and Alk 2 are each, independently of one another, a linear saturated C 1 -C 10 or unsaturated C 2 -C 10 , or branched C 3 -C 10 saturated or unsaturated, alkylene radical (divalent radical); Ph 1 and Ph 2 are each, independently of one another, a phenyl group optionally substituted with one or more radicals, which may be identical or different, selected from among —F, —CF 3 , —R 1 , —OR 1 and —NR 1 R 2 ; R 1 , R 2 and R 3 are each, independently of one another, a linear saturated C 1 -C 7 or unsaturated C 2 -C 7 , or branched or cyclic C 3 -C 7 alkyl radical; or a salt, optical isomer or solvate thereof.