Ser-Trp | 94421-70-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ser-Trp
• 英文别名: Seryltryptophan；(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
• CAS: 94421-70-2
• 化学式: C₁₄H₁₇N₃O₄
• 分子量: 291.307
• InChiKey: LZLREEUGSYITMX-JQWIXIFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  128
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ser-Trp 、 7-methoxycarbonylpterin 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲醇 为溶剂， 以61%的产率得到(2s)-2-[[(2s)-2-[(2-Azanyl-4-Oxidanylidene-1h-Pteridin-7-Yl)carbonylamino]-3-Oxidanyl-Propanoyl]amino]-3-(1h-Indol-3-Yl)propanoic Acid
  参考文献：
  名称：

  Peptide-Conjugated Pterins as Inhibitors of Ricin Toxin A

  摘要：

  Several 7-peptide-substituted pterins were synthesized and tested as competitive active-site inhibitors of ricin toxin A (RTA). Focus began on dipeptide conjugates, and these results further guided the construction of several tripeptide conjugates. The binding of these compounds to RTA was studied via a luminescence-based kinetic assay, as well as through X-ray crystallography. Despite the relatively polar, solvent exposed active site, several hydrophobic interactions, most commonly π-interactions not predicted by modeling programs, were identified in all of the best-performing inhibitors. Nearly all of these compounds provide IC₅₀ values in the low micromolar range.

  DOI：

  10.1021/jm3016393
• 作为产物：
  描述：

  L-色氨酸甲酯盐酸盐 在 N-甲基吗啉 、 palladium on activated charcoal 、 水 、 氢气 、 subtilisin 作用下， 以 四氢呋喃 、 甲醇 、 水 、 叔丁醇 为溶剂， -15.0 ℃ 、500.01 kPa 条件下， 反应 4.0h， 生成 Ser-Trp
  参考文献：
  名称：

  Methods of treatment using water-soluble tryptophan-containing peptides obtained by the hydrolysis of hens eggs lysozyme

  摘要：

  本发明涉及一种生产含水溶性肽且Trp/LNAA比值大于0.15的组合物的过程，包括水解溶菌酶，优选为鸡蛋溶菌酶，制备出具有5至45之间DH的水解物。

  公开号：

  US09228219B2

文献信息

• Identification of Novel<scp>L</scp>-Amino Acid α-Ligases through Hidden Markov Model-Based Profile Analysis
  作者：Akihiro SENOO、Kazuhiko TABATA、Yoshiyuki YONETANI、Makoto YAGASAKI

  DOI：10.1271/bbb.90644

  日期：2010.2.23

  l-Amino acid α-ligase (Lal), catalyzing the formation of α-dipeptides from unprotected l-amino acids in an ATP-dependent manner, is used in cost-effective fermentative production of dipeptides. We searched for novel Lals by in silico screening using Hidden Markov Model-based profile analysis, and identified five novel Lals that showed low similarity and different substrate specificity from known Lals.

  l- 氨基酸 α-连接酶（Lal）以 ATP 依赖性方式催化未受保护的 l- 氨基酸形成 α-二肽，被用于经济高效的二肽发酵生产。我们利用基于隐马尔可夫模型的剖面分析方法，通过硅筛选寻找新型拉尔，结果发现了五种新型拉尔，它们与已知拉尔的相似性较低，底物特异性也不同。
• COMPOSITION FOR ACCELERATION OF ALCOHOL METABOLISM OR RECUPERATION FROM FATIGUE THROUGH GLUCONEOGENESIS
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP1757289A1

  公开（公告）日：2007-02-28

  There is provided a composition useful for mitigating a physical burden and recovering from fatigue at the time of alcohol intake, within a safety dose of active ingredients. The composition is for accelerating alcohol metabolism and for relieving fatigue by gluconeogenesis in vivo, and is characterized by comprising an effective amount of caffeine and an effective amount of an amino acid(s) or a peptide(s) selected from the group consisting of serine, tryptophan, serine rich peptides, tryptophan rich peptides, serine/tryptophan rich peptides and mixtures thereof, as active ingredients.

  本发明提供了一种在有效成分的安全剂量范围内，用于减轻酒精摄入时的身体负担和恢复疲劳的组合物。该组合物用于加速酒精代谢和通过体内糖元生成缓解疲劳，其特征在于包含有效量的咖啡因和有效量的选自丝氨酸、色氨酸、富丝氨酸肽、富色氨酸肽、富丝氨酸/色氨酸肽及其混合物的氨基酸或肽作为活性成分。
• ADDITIVE FOR UNDIFFERENTIATION MAINTAINING MEDIUM
  申请人：Ajinomoto Co., Inc.

  公开号：EP3604503A1

  公开（公告）日：2020-02-05

  The present invention provides a medium for culturing pluripotency stem cells, containing L-tryptophan or L-tryptophan derivative at a concentration of not less than 176 µM.

  本发明提供了一种培养多能干细胞的培养基，其中含有浓度不低于 176 µM 的 L-色氨酸或 L-色氨酸衍生物。
• Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
  申请人：MEITO SANGYO KABUSHIKI KAISHA

  公开号：EP0122151B1

  公开（公告）日：1989-02-15
• Composition For Accelerating Alcohol Metabolism Or Relieving Fatigue By Gluconeogenesis
  申请人：Katayama Yumiko

  公开号：US20070207957A1

  公开（公告）日：2007-09-06

  There is provided a composition useful for mitigating a physical burden and recovering from fatigue at the time of alcohol intake, within a safety dose of active ingredients. The composition is for accelerating alcohol metabolism and for relieving fatigue by gluconeogenesis in vivo, and is characterized by comprising an effective amount of caffeine and an effective amount of an amino acid(s) or a peptide(s) selected from the group consisting of serine, tryptophan, serine rich peptides, tryptophan rich peptides, serine/tryptophan rich peptides and mixtures thereof, as active ingredients.