2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2,4-dichloro-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid allyl ester | 873577-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2,4-dichloro-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid allyl ester
• 英文别名: Prop-2-enyl 2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-3-(2,4-dichlorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate；prop-2-enyl 2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-3-(2,4-dichlorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
• CAS: 873577-68-5
• 化学式: C₂₆H₃₈Cl₂N₂O₄Si
• 分子量: 541.59
• InChiKey: QPENBJPHZAJAAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.69
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2,4-dichloro-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid allyl ester 在 jones reagent 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 丙酮 为溶剂， 生成 3-(2,4-Dichloro-phenyl)-1-oxo-2-[(3-piperidin-1-yl-propylcarbamoyl)-methyl]-2,8-diaza-spiro[4.5]decane-8-carboxylic acid allyl ester
  参考文献：
  名称：

  Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists

  摘要：

  The synthesis of racemic and non-racemic spirocyclic lactams that display high binding affinity toward CCR4 is described. Two distinct series of spirocycles were prepared from the common intermediate 9. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.139
• 作为产物：
  描述：

  4-(2,4-二氯苯基)-4-氧代丁酸 在 咪唑 、 三乙基硅烷 、 四氯化钛 、 三乙酰氧基硼氢化钠 、 臭氧 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 甲苯 、 乙腈 为溶剂， 反应 32.0h， 生成 2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2,4-dichloro-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid allyl ester
  参考文献：
  名称：

  Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists

  摘要：

  The synthesis of racemic and non-racemic spirocyclic lactams that display high binding affinity toward CCR4 is described. Two distinct series of spirocycles were prepared from the common intermediate 9. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.139

文献信息

• Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists
  作者：Joshua D. Hansen、Bradley J. Newhouse、Shelley Allen、Aaron Anderson、Todd Eary、Justin Schiro、John Gaudino、Ellen Laird、Andrew C. Allen、David Chantry、Christine Eberhardt、Laurence E. Burgess

  DOI：10.1016/j.tetlet.2005.10.139

  日期：2006.1

  The synthesis of racemic and non-racemic spirocyclic lactams that display high binding affinity toward CCR4 is described. Two distinct series of spirocycles were prepared from the common intermediate 9. (c) 2005 Elsevier Ltd. All rights reserved.