O-(1-甲基-2-丙烯基)羟胺盐酸盐 | 71350-16-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: O-(1-甲基-2-丙烯基)羟胺盐酸盐
• 英文名称: O-(α-methyl)allylhydroxylamine hydrochloride
• 英文别名: O-(1-Methyl-allyl)-hydroxylamine hydrochloride；O-but-3-en-2-ylhydroxylamine;hydrochloride
• CAS: 71350-16-8
• 化学式: C₄H₉NO*ClH
• 分子量: 123.582
• InChiKey: XHWRUHZKMMUWFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.87
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 包装等级：
  II
• 危险类别：
  4.1
• 危险性防范说明：
  P240,P210,P241,P264,P280,P302+P352,P370+P378,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险品运输编号：
  1325
• 危险性描述：
  H228,H315,H319

反应信息

• 作为反应物：
  描述：

  O-(1-甲基-2-丙烯基)羟胺盐酸盐 、 环己酮 在 sodium acetate 、 sodium carbonate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以94%的产率得到cyclohexanone oxime O-(α-methyl)allyl ether
  参考文献：
  名称：

  Koyama, Junko; Sugita, Teruyo; Suzuta, Yukio, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 8, p. 2601 - 2606

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(1-methyl-allyloxy)-phthalimide 、 肼 生成 O-(1-甲基-2-丙烯基)羟胺盐酸盐
  参考文献：
  名称：

  IRIE H.; KATAYAMA I.; MIZUNO Y.; KOYAMA J.; SUZUTA Y., HETEROCYCLES, 1979, 12, NO 6, 771-773

  摘要：

  DOI：

文献信息

• Synthesis, and In vitro and In vivo muscarinic pharmacological properties of a series of 1,6-Dihydro-5-(4 H )-pyrimidinone oximes
  作者：Ralf Plate、Marc J.M. Plaum、Peter Pintar、Christan G. Jans、Thijs de Boer、Fred A. Dijcks、Ge Ruigt、John S. Andrews

  DOI：10.1016/s0968-0896(98)00074-1

  日期：1998.9

  A series of 1,6-dihydro-5-(4H)-pyrimidinone oxime derivatives I was synthesized (Scheme 1, Tables 1 and 2) and tested for muscarinic activity (Table 3) in receptor binding assays using [H-3]-oxotremorine-M (Oxo-M) and [H-3]-pirenzepine pirenzepine (Pz) as ligands. Potential muscarinic agonistic or antagonistic properties of the compounds were determined using binding studies that measured their potencies to inhibit the binding of Oxo-M and Pz. Preferential inhibition of Oxo-M binding was used as an indicator for potential muscarinic agonistic properties; this potential was confirmed in functional studies on isolated organs. The series produced a wide range of active compounds with differing degrees of selectivity in M-1, M-2, and M-3 functional models. Several compounds that have mixed agonist/antagonist profiles were able to reduce cholinergic-related cognitive impairments in models of mnemonic function. Substitutions (I, e.g. R-2 or R-3 = Me) at the 1,6-dihydro-5-(4H)pyrimidine ring disrupted binding and efficacy, whereas systematic variation of the oximes substituent R1 resulted in various degrees of potency and selectivity dependent on the nature of the substitution. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Koyama, Junko; Sugita, Teruyo; Suzuta, Yukio, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 8, p. 2601 - 2606
  作者：Koyama, Junko、Sugita, Teruyo、Suzuta, Yukio、Irie, Hiroshi

  DOI：——

  日期：——
• IRIE H.; KATAYAMA I.; MIZUNO Y.; KOYAMA J.; SUZUTA Y., HETEROCYCLES, 1979, 12, NO 6, 771-773
  作者：IRIE H.、 KATAYAMA I.、 MIZUNO Y.、 KOYAMA J.、 SUZUTA Y.

  DOI：——

  日期：——