O-(2-甲氧基乙基)羟胺盐酸盐 | 82172-73-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: O-(2-甲氧基乙基)羟胺盐酸盐
• 英文名称: O-(2-methoxy-ethyl)-hydroxylamine hydrochloride
• 英文别名: O-(2-Methoxyethyl)hydroxylamine hydrochloride；O-(2-methoxyethyl)hydroxylamine;hydrochloride
• CAS: 82172-73-4
• 化学式: C₃H₉NO₂*ClH
• mdl: MFCD22056494
• 分子量: 127.571
• InChiKey: PIGOQGWUUYLYLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.41
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P330,P363,P501
• 危险性描述：
  H302,H312,H332

反应信息

• 作为反应物：
  描述：

  O-(2-甲氧基乙基)羟胺盐酸盐 、 4,4'-二羟基二苯甲酮 以 乙醇 为溶剂， 以95%的产率得到bis(4-hydroxyphenyl)methanone O-(2-methoxyethyl) oxime
  参考文献：
  名称：

  Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism

  摘要：

  In this study, a series of bis(4-hydroxy) benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have additional and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2016.01.089
• 作为产物：
  描述：

  2-(2-甲氧乙氧基)异吲哚-1,3-二酮 在 一水合肼 作用下， 以 二氯甲烷 为溶剂， 生成 O-(2-甲氧基乙基)羟胺盐酸盐
  参考文献：
  名称：

  [EN] TRICYCLIC-CONTAINING MACROCYCLIC COMPOUND AND USE THEREOF
  [FR] COMPOSÉ MACROCYCLIQUE CONTENANT UN TRICYCLIQUE ET SON UTILISATION
  [ZH] 含三并环的大环类化合物及其应用

  摘要：

  本发明公开了一类含三并环的大环类化合物及其应用，具体公开了式(II)所示化合物及其药学上可接受的盐。

  公开号：

  WO2024017380A1

文献信息

• [EN] THIAZOLYL-DIHYDRO-INDAZOLES<br/>[FR] THIAZOLYLDIHYDROINDAZOLES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009112565A1

  公开（公告）日：2009-09-17

  The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）中R1至R3的化合物，其中R1至R3的定义如权利要求书中所述，适用于治疗以细胞过度或异常增殖为特征的疾病，并用于制备具有上述特性的药物。
• Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncology
  申请人：Aventis Pharma S.A.

  公开号：US20040162276A1

  公开（公告）日：2004-08-19

  The present invention relates to novel compounds derived from indazoles or indoles of formula (1) or formula (2), to methods for treating tumors or cancerous cells with compounds of formula (1) or formula (2) and to pharmacaetutical compositions comprising a pharmaceutically acceptable carrier and a compound of formula (1) or formula (2). 1

  本发明涉及从式（1）或式（2）的吲唑或吲哚衍生的新化合物，以及使用式（1）或式（2）的化合物治疗肿瘤或癌细胞的方法，还涉及包含药学上可接受的载体和式（1）或式（2）化合物的药物组合物。
• FUSED NITROGEN-COMPRISING HETEROCYCLIC COMPOUND
  申请人：Seto Masaki

  公开号：US20100234351A1

  公开（公告）日：2010-09-16

  A compound of the formula: wherein ring A is a 7-membered or 8-membered nitrogen-containing ring optionally further substituted, ring B is an optionally substituted aryl group or an optionally substituted heteroaryl group, X 1 is a group represented by —NR 3 —Y 1 —, —O—, —S—, —SO—, —SO 2 — or —CHR 3 — wherein R 3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R 3 may be bonded to the carbon atom of ring B to form an optionally substituted ring structure, and Y 1 is a bond or an optionally substituted alkylene, R 1 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom or a sulfur atom, the formula shows a single bond or a double bond, when R 2 is —R 2 , R 2 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, and when R 2 is ═R 2 , R 2 is an oxo group, an optionally substituted alkylidene group, or an optionally substituted imino group.

  该化合物的化学式为：其中环A是一个7-或8-成员的含氮环，可选择进一步取代，环B是一个可选择取代的芳基或杂芳基，X1是一个由—NR3—Y1—、—O—、—S—、—SO—、—SO2—或—CHR3—表示的基团，其中R3是氢原子或可选择取代的脂肪烃基团，或R3可与环B的碳原子结合形成可选择取代的环结构，Y1是一个键或可选择取代的烷基，R1是氢原子或通过碳原子或硫原子结合的可选择取代的基团，化学式中显示单键或双键，当R2是—R2时，R2是氢原子或通过碳原子结合的可选择取代的基团，氮原子、氧原子或硫原子，当R2是═R2时，R2是一个氧代基团、可选择取代的烷基亚甲基基团或可选择取代的亚胺基团。
• CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES
  申请人：Herrmann Andreas

  公开号：US20100226875A1

  公开（公告）日：2010-09-09

  The present invention relates to a dynamic mixture in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one O-substituted hydroxylamine or S-substituted thiohydroxylamine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide or fungicide aldehyde or ketone. This mixture is capable of releasing in a controlled and prolonged manner the aldehyde or ketone into the surrounding environment. Furthermore, the present invention concerns also the use of these dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles that include these mixtures.

  本发明涉及一种动态混合物，其为通过在水的存在下将至少一种O-取代羟胺或S-取代硫羟胺衍生物与至少一种香料、调味剂、驱虫剂或诱引剂、杀菌剂或杀真菌剂醛或酮反应而得到的动态混合物。该混合物能够以受控且持久的方式释放出醛或酮到周围环境中。此外，本发明还涉及将这些动态混合物用作香料成分以及包括这些混合物的香料组合物或香料物品的使用。
• [EN] TRICYCLIC-CONTAINING MACROCYCLIC COMPOUND AND USE THEREOF<br/>[FR] COMPOSÉ MACROCYCLIQUE CONTENANT UN TRICYCLIQUE ET SON UTILISATION<br/>[ZH] 含三并环的大环类化合物及其应用
  申请人：[en]MEDSHINE DISCOVERY INC.;[zh]南京明德新药研发有限公司

  公开号：WO2024017380A1

  公开（公告）日：2024-01-25

  本发明公开了一类含三并环的大环类化合物及其应用，具体公开了式(II)所示化合物及其药学上可接受的盐。