(E)-5-(4-hydroxy-3-methoxyphenyl)-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3-oxopent-4-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-5-(4-hydroxy-3-methoxyphenyl)-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3-oxopent-4-enamide
• 化学式: C₂₃H₂₄N₂O₅
• 分子量: 408.4
• InChiKey: HFAWMFCETNQPEX-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US20160289187A1

  公开（公告）日：2016-10-06

  Hybrid compounds of curcumin and melatonin as neuroprotectants are provided. The hybrid compounds are useful for the treatment and/or prevention of Alzheimer's disease (AD), as well as other neurodegenerative diseases. The hybrid compounds exhibited superior and potent neuroprotection in an AD model.
• US9738605B2
  申请人：——

  公开号：US9738605B2

  公开（公告）日：2017-08-22