毒理性
哺乳期使用概述：在哺乳期间短期或偶尔使用二氯醛苯那宗不太可能对哺乳的婴儿产生不利影响，特别是如果婴儿年龄超过2个月。由于活性代谢物三氯乙醇的半衰期较长，长期在哺乳期间重复使用可能会导致婴儿镇静，尤其是在哺乳新生儿或早产儿时。在组合偏头痛产品（例如，Midrin）中发现的低剂量二氯醛苯那宗不太可能导致婴儿嗜睡，除非每天多次重复剂量。二氯醛苯那宗中的安替比林成分被认为不太可能对婴儿造成伤害。监测婴儿是否有镇静、进食不良和体重增长不良的情况。
对哺乳婴儿的影响：一名5个月大的哺乳婴儿在其母亲每晚服用1.3克二氯醛苯那宗（相当于大约1克水合氯醛）加氯丙嗪100毫克每日3次的情况下，出现了轻微的早晨镇静。婴儿在3个月大时的整体发育被认为是正常的。
对泌乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。
◉ Summary of Use during Lactation:Short-term or occasional use of dichloralphenazone during breastfeeding is unlikely to adversely affect the breastfed infant, especially if the infant is older than 2 months. Because the active metabolite, trichloroethanol, has a long half-life, long-term use of repeated doses during breastfeeding could result in infant sedation, especially while nursing a neonate or preterm infant. The low doses of dichloralphenazone found in combination migraine products (e.g., Midrin) are less likely to cause drowsiness in the infant unless doses are repeated several times daily. The antipyrine component of dichloralphenazone is considered unlikely to harm the infant. Monitor the infant for sedation, poor feeding and poor weight gain.
◉ Effects in Breastfed Infants:Minimal morning sedation occurred in a 5-month-old breastfed infant whose mother was taking 1.3 grams of dichloralphenazone (equivalent to about 1 gram of chloral hydrate) every evening plus chlorpromazine 100 mg 3 times daily. The infant's overall development was said to be normal at 3 months of age.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
