(E)-1-pyridin-3-yl-3-quinolin-2-ylprop-2-en-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-1-pyridin-3-yl-3-quinolin-2-ylprop-2-en-1-one
• 化学式: C₁₇H₁₂N₂O
• 分子量: 260.29
• InChiKey: ICATWAFCVSJZPS-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• FAMILY OF PFKFB3 INHIBITORS WITH ANTI-NEOPLASTIC ACTIVITIES
  申请人：University Of Louisville Research Foundation, Inc.

  公开号：EP2167058B1

  公开（公告）日：2015-08-12
• METHODS AND SYSTEMS FOR CHARACTERIZING SEVERE CROHN'S DISEASE
  申请人：CEDARS-SINAI MEDICAL CENTER

  公开号：US20210079473A1

  公开（公告）日：2021-03-18

  The present disclosure describes methods, devices and systems of diagnosing, prognosing, and treating subjects with moderate to severe forms of Crohn's disease (CD) that is characterized by stricturing and internal penetrating disease phenotypes. Also described are methods and kits for characterizing a subtype of CD, and identifying a subject as being suitable for a therapy to treat the CD.
• US8088385B2
  申请人：——

  公开号：US8088385B2

  公开（公告）日：2012-01-03
• US8557823B2
  申请人：——

  公开号：US8557823B2

  公开（公告）日：2013-10-15
• [EN] METHODS AND COMPOSITIONS FOR DIABETES TREATMENT AND BETA-CELL REGENERATION<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU DIABÈTE ET LA RÉGÉNÉRATION DE CELLULES BÊTA
  申请人：UNIV CALIFORNIA

  公开号：WO2022040161A1

  公开（公告）日：2022-02-24

  Aspects of the present disclosure are directed to methods and compositions for facilitating β-cell regeneration by inhibition of the HIF1α-PFKFB3 pathway. Certain aspects describe methods for treatment and prevention of prediabetes and diabetes, including type 2 diabetes. Also disclosed are methods and compositions for enhancing β-cell regeneration.