O4-甲基-D-半乳糖 | 14199-59-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: O4-甲基-D-半乳糖
• 英文名称: 4-o-Methyl-β-D-Galactose
• 英文别名: 4-O-Methylmannose；6-(hydroxymethyl)-5-methoxyoxane-2,3,4-triol
• CAS: 14199-59-8；25029-37-2；27552-11-0；31505-21-2；31505-22-3；31505-25-6；55058-39-4；55058-41-8；119720-61-5；120787-75-9
• 化学式: C₇H₁₄O₆
• 分子量: 194.185
• InChiKey: UGQUOHHDWLIZQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] INHIBITORS OF ALDOSE REDUCTASE<br/>[FR] INHIBITEURS DE L'ALDOSE RÉDUCTASE
  申请人：APPLIED THERAPEUTICS INC

  公开号：WO2020205846A1

  公开（公告）日：2020-10-08

  The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, cardiomyopathy, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, galactosemia, asthma, PMM2-CDG and the like.

  本公开涉及新颖化合物及其药物组合物，以及促进皮肤健康老化、治疗皮肤疾病、心血管疾病、肾脏疾病、血管生成障碍（如癌症）、组织损伤治疗（如非心脏组织损伤）、心肌梗死演变治疗、缺血性损伤治疗以及利用本发明的化合物和组合物治疗糖尿病引起的并发症等方法。其他疾病可能包括但不限于动脉粥样硬化、心肌病、冠状动脉疾病、糖尿病肾病、糖尿病神经病变、糖尿病视网膜病变、糖尿病心肌病、皮肤感染、外周血管疾病、中风、半乳糖血症、哮喘、PMM2-CDG等。
• AN IMPROVED PROCESS FOR THE PREPARATION OF SUGAMMADEX
  申请人：FRESENIUS KABI IPSUM S.R.L.

  公开号：US20190284308A1

  公开（公告）日：2019-09-19

  The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-γ-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.

  本申请提供了一种改进的方法，通过在适宜的有机溶剂中将3-巯基丙酸盐与6-去氧-6-卤代-γ-环糊精反应，制备sugammadex。本申请还提供了3-巯基丙酸盐的晶体形式，优选为3-巯基丙酸二钠盐，以及其用于制备sugammadex。式（I）显示了sugammadex的钠盐。
• Process for the preparation of sugammadex
  申请人：FRESENIUS KABI IPSUM S.R.L.

  公开号：US10577433B2

  公开（公告）日：2020-03-03

  The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-γ-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.

  本申请提供了一种制备舒降之胺的改进工艺，该工艺通过在合适的有机溶剂中使 3-巯基丙酸的一种盐与 6-脱氧-6-全卤-γ-环糊精反应来制备舒降之胺。本申请还提供了 3-巯基丙酸盐（最好是 3-巯基丙酸二钠盐）的结晶形式及其用于制备舒降之胺的用途，而式（I）表示舒降之胺的钠盐。
• ANTIFREEZE GLYCOPROTEIN ANALOGUES AND USES THEREOF
  申请人：Ben Robert N.

  公开号：US20100068692A1

  公开（公告）日：2010-03-18

  An antifreeze glycoprotein comprising at least one C-linked saccharide according to the following general formula: wherein X is nitrogen, sulfur, carbon or (CR 1 R 2 ) n S═O wherein n is 0, 1, 2 or 3, Y is carbon, nitrogen, sulfur or oxygen, R 1 is hydrogen, methyl, fluorine, a carbohydrate, or a hydroxy chain, R 2 is hydrogen, methyl, fluorine, a carbohydrate or a hydroxy chain, R 3 to R 6 independently represent an alkyl chain, a hydroxy group, a dimethyl sulfoxy group, a carbohydrate or an ether, R 7 is ornithine, lysine, an alkyl chain, a pyridyl group or a heterocycle; and R 8 is hydrogen, fluorine a carbohydrate or a hydroxy or methoxy group. Such antifreeze glycoprotein analogues are useful recrystallization inhibitors and may be used as a cryoprotectant for tissue preservation and transplantation, improving the texture of processed frozen food and frozen meats, frostbite protection, crop protection, and green alternatives for land vehicle antifreeze and aircraft de-icing.
• Processing Biomass and Petroleum Containing Materials
  申请人：XYLECO, INC.

  公开号：US20130261340A1

  公开（公告）日：2013-10-03

  Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol and/or butanol, e.g., by fermentation.