ICR 191 Acridine | 17070-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ICR 191 Acridine
• 英文别名: ICR-191；N-(2-Chlor-ethyl)-N'-<6-chlor-2-methoxy-acridinyl-(9)>-trimethylendiamin；Acridine half-mustard；N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)propane-1,3-diamine
• CAS: 17070-44-9
• 化学式: C₁₉H₂₁Cl₂N₃O
• 分子量: 378.301
• InChiKey: OAPNFEMIOBGOHM-UHFFFAOYSA-N

物化性质

• 物理描述：
  Icr 191 appears as yellow crystalline or chunky solid. (NTP, 1992)
• 熔点：
  520 to 523 °F (decomposes) (NTP, 1992)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

文献信息

• Aminopyridinemethanol compounds and their use
  申请人：UNIVERSITE AMIENS PICARDIE JULES VERNE

  公开号：US11220482B2

  公开（公告）日：2022-01-11

  The present invention is directed to novel compounds of Formula (I): pharmaceutically acceptable salts or solvates thereof, and their use, in particular in the treatment or prevention of malaria.

  本发明涉及新型的式 (I) 化合物：其药学上可接受的盐或溶液及其用途，特别是在治疗或预防疟疾方面。
• GENETICALLY MODIFIED MICROORGANISMS CAPABLE OF PRODUCING BETA-GLUCANS AND METHODS FOR PRODUCING BETA-GLUCANS
  申请人：Wintershall Holding GmbH

  公开号：EP2870239A1

  公开（公告）日：2015-05-13
• NOVEL AMINOPYRIDINEMETHANOL COMPOUNDS AND THEIR USE
  申请人：Université Amiens Picardie Jules Verne

  公开号：EP3704093A1

  公开（公告）日：2020-09-09
• Method for detecting mutagenic substances
  申请人：Reifferscheid Georg

  公开号：US20050070006A1

  公开（公告）日：2005-03-31

  The invention relates to a method and means for the rapid identification of mutations. The test strains used in the invention contain a reporter system and a selection marker. An antibiotic resistance protein which after mutation allows the selective growth of the revertant and the targeted induction of the inducible reporter system of the developing revertants acts as the selection marker. Proteins that are capable of directly or indirectly triggering a measuring signal are used as the reporters. The mutations are identified by means of the reporter signal of the developing revertants, in such a way that the evaluation can take place after only a few hours.
• [EN] GENETICALLY MODIFIED MICROORGANISMS CAPABLE OF PRODUCING BETA-GLUCANS AND METHODS FOR PRODUCING BETA-GLUCANS<br/>[FR] MICROORGANISMES GÉNÉTIQUEMENT MODIFIÉS POUVANT PRODUIRE DES BÊTA-GLUCANES ET PROCÉDÉS POUR LA PRODUCTION DE BÊTA-GLUCANES
  申请人：WINTERSHALL HOLDING GMBH

  公开号：WO2014006088A1

  公开（公告）日：2014-01-09

  The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans.