3-(4-(4-(Benzo(g)quinolin-4-ylamino)phenyl)piperazin-1-yl)propan-1-ol | 127136-39-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(4-(4-(Benzo(g)quinolin-4-ylamino)phenyl)piperazin-1-yl)propan-1-ol
• 英文别名: 3-[4-[4-(benzo[g]quinolin-4-ylamino)phenyl]piperazin-1-yl]propan-1-ol
• CAS: 127136-39-4
• 化学式: C₂₆H₂₈N₄O
• 分子量: 412.5
• InChiKey: ZRXNTCOXXLCXJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  51.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• US6274596B1
  申请人：——

  公开号：US6274596B1

  公开（公告）日：2001-08-14
• [EN] BENZOQUINOLINE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES DE BENZOQUINOLINE UTILES COMME ANTIBACTERIENS
  申请人：SCRIPTGEN PHARM INC

  公开号：WO2000024389A2

  公开（公告）日：2000-05-04

  Disclosed are pharmaceutical compositions and formulations comprising benzoquinoline derivatives having formulas (I) to (V). In formula (I), X i selected from the group consisting of O, S, CH2, CH2-CH2, C=O or NR8; Z is C or N; R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, halogen, linear or branched chain lower alkyl, alkenyl, alkynyl, alkoxy or acyl; X-RA and R3, or R3 and R4 are optionally linked together to form a ring or a salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed are methods of inhibiting bacterial growth, comprising the administration of formulations comprising the compounds of formulas (I) to (V).