5-(1-hydroxy-2-isopropylamino)butyl-8-hydroxycarbostyril hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(1-hydroxy-2-isopropylamino)butyl-8-hydroxycarbostyril hydrochloride
• 英文别名: hydron;8-hydroxy-5-[(1R,2S)-1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one;chloride
• 化学式: C₁₆H₂₂N₂O₃*ClH
• 分子量: 326.823
• InChiKey: AEQDBKHAAWUCMT-CVHDTDHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.88
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.437
• 拓扑面积：
  81.6
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• EP2576778B1
  申请人：——

  公开号：EP2576778B1

  公开（公告）日：2017-08-09
• TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS
  申请人：Hagiwara Masatoshi

  公开号：US20130137099A1

  公开（公告）日：2013-05-30

  An object of the present invention is to develop a new alternative splicing reporter system and to provide a method for detecting alternative splicing patterns in a mammalian multicellular organism more precisely, a method for identifying efficiently substances and gene regions that affect alternative splicing in a mammalian multicellular organism, and the like by utilizing the alternative splicing reporter system. Specifically, the present invention relates to a method for detecting alternative splicing in a mammalian multicellular organism, and a method for identifying substances and gene regions that affect alternative splicing in a mammalian multicellular organism, which use a DNA construct in which at least two different reporter genes are inserted into a specific gene that undergoes alternative splicing, or a combination of DNA constructs (a combination of at least two different DNA constructs) in which DNA construct a reporter gene is inserted into a specific gene that undergoes alternative splicing.
• US7790905B2
  申请人：——

  公开号：US7790905B2

  公开（公告）日：2010-09-07
• US7927613B2
  申请人：——

  公开号：US7927613B2

  公开（公告）日：2011-04-19
• US9273364B2
  申请人：——

  公开号：US9273364B2

  公开（公告）日：2016-03-01