1-Benzyl-3-ethyl-6,7-dimethoxyisoquinolinium chloride;1-Benzyl-3-ethyl-6,7-dimethoxyisoquinolinium chloride | 1163-37-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-Benzyl-3-ethyl-6,7-dimethoxyisoquinolinium chloride;1-Benzyl-3-ethyl-6,7-dimethoxyisoquinolinium chloride
• 英文别名: 1-benzyl-3-ethyl-6,7-dimethoxyisoquinolin-2-ium;chloride
• CAS: 1163-37-7
• 化学式: C20H22ClNO2
• 分子量: 343.8
• InChiKey: DULZSDGCXSLVAQ-UHFFFAOYSA-N

物化性质

• 熔点：
  208-210° (dec)

计算性质

• 辛醇/水分配系数(LogP)：
  4.83
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  31.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
  申请人：The Scripps Research Institute

  公开号：US10660899B2

  公开（公告）日：2020-05-26

  The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

  本发明提供了用神经递质受体调节剂诱导少突胶质祖细胞向成熟髓鞘细胞命运分化的方法。本发明还提供了通过施用所述神经递质受体调节剂刺激有需要的受试者增加髓鞘化的方法。本发明还提供了使用神经递质受体调节剂治疗脱髓鞘疾病的方法。
• Use of papaverine-like vasodilator and pharmaceutical composition
  申请人：Gross Dorothea

  公开号：US20060058345A1

  公开（公告）日：2006-03-16

  The invention concerns the use of papaverine-like vasodilator for the production of a pharmaceutical composition for the treatment of ophthalmological dysfunctions which are linked to circulatory disturbances of the eye or which are to be attributed to circulatory disturbances of the eye, wherein the pharmaceutical composition is to be applied topically to the eye. The invention further concerns a pharmaceutical composition which includes papaverine-like vasodilator and pharmacologically compatible viscosity regulator.

  本发明涉及使用类罂粟碱血管扩张剂生产一种药物组合物，用于治疗与眼部循环障碍有关或可归因于眼部循环障碍的眼科功能障碍，其中该药物组合物可局部用于眼部。本发明还涉及一种药物组合物，其中包括类木瓜碱血管扩张剂和药理兼容的粘度调节剂。
• VORRICHTUNG ZUR GELENKARTIGEN VERBINDUNG ZWEIER KÖRPER
  申请人：Synthes GmbH

  公开号：EP1274354B8

  公开（公告）日：2007-04-18
• DEVICE AND METHOD FOR APPLYING EXTERNAL PRESSURE IN COMBINATION WITH COAGULANT TREATMENT OF PUNCTURE WOUNDS
  申请人：RADI MEDICAL SYSTEMS AB

  公开号：EP1455659A1

  公开（公告）日：2004-09-15
• RAPID DIAGNOSTIC STRIP COMPRISING A MOISTURE-ABSORBING MATERIAL AND THE BLISTER PACKAGING THEREOF
  申请人：Certest Biotec, S.L.

  公开号：EP1754971B1

  公开（公告）日：2008-06-25