4,4'-(1,4-Piperazinediylbis((1-methylethylene)imino))bis(7-chloroquinoline) | 10547-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4,4'-(1,4-Piperazinediylbis((1-methylethylene)imino))bis(7-chloroquinoline)
• 英文别名: 7-chloro-N-[2-[4-[2-[(7-chloroquinolin-4-yl)amino]propan-2-yl]piperazin-1-yl]propan-2-yl]quinolin-4-amine
• CAS: 10547-40-7
• 化学式: C₂₈H₃₂Cl₂N₆
• 分子量: 523.5
• InChiKey: UBZRQVAGRBEYDI-UHFFFAOYSA-N

物化性质

• 熔点：
  270-271 °C
• 沸点：
  720.3±60.0 °C(Predicted)
• 密度：
  1.296±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  56.3
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2933990090

文献信息

• ANTIMALARIAL THERAPY USING A COMBINATION OF SYNTHETIC ARTEMISININ DERIVATIVE AND BISQUINOLINE DERIVATIVE
  申请人：Ranbaxy Laboratories Limited

  公开号：EP2026795A2

  公开（公告）日：2009-02-25
• TREATMENTS FOR NEUROPATHY
  申请人：Children's Medical Center Corporation

  公开号：EP2240177A2

  公开（公告）日：2010-10-20
• PIPERAQUINE MICROCAPSULES AND COMPOSITIONS CONTAINING THEM
  申请人：ADARE PHARMACEUTICALS S.R.L.

  公开号：EP2976069A1

  公开（公告）日：2016-01-27
• Treatments for Neuropathy
  申请人：Corfas Gabriel

  公开号：US20110086878A1

  公开（公告）日：2011-04-14

  Small fiber neuropathy is treated or prevented by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat or prevent neuropathy in the subject. Glial cell-derived neurotrophic factor (GDNF) receptors are modulated with the subject active quinoline compounds, which may be formulated in topical lotions.
• COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY
  申请人：CHILDEREN'S MEDICAL CENTER CORPORATION

  公开号：US20160045487A1

  公开（公告）日：2016-02-18

  The invention features XIB4035 for the treatment of large fiber neuropathy, and combinations of XIB4035 and GDNF for the treatment of both large and small fiber neuropathies.