D-Glucuronic acid, 2-(acetylamino)-2-deoxy- | 34047-66-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-Glucuronic acid, 2-(acetylamino)-2-deoxy-
• 英文别名: (2S,3S,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxohexanoic acid
• CAS: 34047-66-0
• 化学式: C₈H₁₃NO₇
• 分子量: 235.19
• InChiKey: MQWZJOSNNICZJE-VZFHVOOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  144
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Esters of hyaluronic acid and their salts.
  申请人：FIDIA S.p.A.

  公开号：EP0216453A2

  公开（公告）日：1987-04-01

  The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases. The compounds possess interesting and precious bio- plastic and pharmaceutical properties and may be used in innumerable fields, including cosmetics, surgery and medicine. The invention also includes pharmaceutical preparations containing, as an active ingredient, one or more hyaluronic acid esters, or a salt thereof as described above, as well as medicaments containing: 1) a pharmacologically active substance or an association of pharmacologically active substances and 2) a carrying vehicle containing a total or partial ester of hyaluronic acid. The invention includes also various uses of the hyaluronic esters or of the above mentioned medicaments, such as in medicine, surgery or cosmetics. The invention also relates to a new procedure for the preparation of polysaccharide esters containing carboxylic groups, such as in particular the above mentioned hayluronic acid esters.

  本发明涉及全部或仅部分羧基被酯化的透明质酸酯，以及部分酯与金属或药理学上可接受的有机碱的盐。 这些化合物具有有趣而珍贵的生物塑料和药物特性，可用于无数领域，包括化妆品、外科手术和医药。本发明还包括含有一种或多种透明质酸酯或其上述盐类作为活性成分的药物制剂，以及含有以下成分的药品： 1) 一种药理活性物质或药理活性物质的组合，以及 2) 含有全部或部分透明质酸酯的载体。 本发明还包括透明质酸酯或上述药剂的各种用途，如医药、外科手术或化妆品。 本发明还涉及一种制备含有羧基的多糖酯的新工艺，特别是上述海藻糖酸酯。
• Polysaccharide esters and their salts
  申请人：FIDIA S.p.A.

  公开号：EP0696598A1

  公开（公告）日：1996-02-14

  The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases. The compounds possess interesting and precious bioplastic and pharmaceutical properties and may be used in innumerable fields, including cosmetics, surgery and medicine. The invention also includes pharmaceutical preparations containing, as an active ingredient, one or more hyaluronic acid esters, or a salt thereof as described above, as well as medicaments containing: 1) a pharmacologically active substance or an association of pharmacologically active substances and 2) a carrying vehicle containing a total or partial ester of hyaluronic acid. The invention includes also various uses of the hyaluronic esters or of the above mentioned medicaments, such as in medicine, surgery or cosmetics. The invention also relates to a new procedure for the preparation of polysaccharide esters containing carboxylic groups, such as in particular the above mentioned hayluronic acid esters.

  本发明涉及全部或仅部分羧基被酯化的透明质酸酯，以及部分酯与金属或药理学上可接受的有机碱的盐。 这些化合物具有有趣而珍贵的生物塑性和药用特性，可用于化妆品、外科手术和医药等众多领域。本发明还包括含有一种或多种透明质酸酯或其上述盐类作为活性成分的药物制剂，以及含有以下成分的药品： 1) 一种药理活性物质或药理活性物质的组合，以及 2) 含有全部或部分透明质酸酯的载体。 本发明还包括透明质酸酯或上述药剂的各种用途，如医药、外科手术或化妆品。 本发明还涉及一种制备含有羧基的多糖酯的新工艺，特别是上述海藻糖酸酯。
• US4851521A
  申请人：——

  公开号：US4851521A

  公开（公告）日：1989-07-25
• US4965353A
  申请人：——

  公开号：US4965353A

  公开（公告）日：1990-10-23
• US5202431A
  申请人：——

  公开号：US5202431A

  公开（公告）日：1993-04-13