3-Acetamido-3-phenylacrylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-Acetamido-3-phenylacrylic acid
• 英文别名: (E)-3-acetamido-3-phenylprop-2-enoic acid
• 化学式: C₁₁H₁₁NO₃
• 分子量: 205.21
• InChiKey: QQBDEJVYLGPZKS-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Process for the preparation of enantiomerically enriched n-acyl-beta-amino acid derivatives by enantioselective hydrogenation of the corresponding (z)-enamides
  申请人：——

  公开号：US20040186314A1

  公开（公告）日：2004-09-23

  A process for the preparation of an enantiomerically enriched beta-amino acid derivative of formula (1), or the opposite enantiomer thereof, wherein R1 is an optionally substituted alkyl, aryl or heteroaryl group of up to 20 C atoms, R2 is ann alkyl group of up to 20 C atoms, and R3 is H or an alkyl or aryl group of up to 20 C atoms, which comprises asymmetric hydrogenation of the (z)-enamide precursor (2) in an alcohol solvent or cosolvent, catalysed by a cationic rhodium complex of a chiral phosphine ligand having the partial formula (3), wherein n is 0 to 6 and R represents at least one non-hydrogen organic group of up to 20 C atoms.

  一种制备对映体富集的式(1)β-氨基酸衍生物或其对映体的工艺，其中 R1 是一个最多 20 个 C 原子的任选取代的烷基、芳基或杂芳基，R2 是一个最多 20 个 C 原子的烷基，R3 是 H 或一个最多 20 个 C 原子的烷基或芳基、其中包括(z)-烯酰胺前体(2)在醇溶剂或助溶剂中的不对称氢化，由具有部分式(3)的手性膦配体的阳离子铑络合物催化，其中 n 为 0 至 6，R 代表至少一个不超过 20 个 C 原子的非氢有机基团。
• PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED N-ACYL-BETA-AMINO ACID DERIVATIVES BY ENANTIOSELECTIVE HYDROGENATION OF THE CORRESPONDING (Z)-ENAMIDES
  申请人：DOW GLOBAL TECHNOLOGIES INC.

  公开号：EP1421059A1

  公开（公告）日：2004-05-26
• [EN] PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED N-ACYL-BETA-AMINO ACID DERIVATIVES BY ENANTIOSELECTIVE HYDROGENATION OF THE CORRESPONDING (Z)-ENAMIDES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES DE N-ACYL-BETA-AMINO ACIDES ENRICHIS EN ENANTIOMERES PAR HYDROGENATION ENANTIOSELECTIVE DE (Z)-ENAMIDES CORRESPONDANTS
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2003016264A1

  公开（公告）日：2003-02-27

  A process for the preparation of an enantiomerically enriched beta-amino acid derivative of formula (1), or the opposite enantiomer thereof, wherein R1 is an optionally substituted alkyl, aryl or heteroaryl group of up to 20 C atoms, R2 is ann alkyl group of up to 20 C atoms, and R3 is H or an alkyl or aryl group of up to 20 C atoms, which comprises asymmetric hydrogenation of the (z)-enamide precursor (2) in an alcohol solvent or cosolvent, catalysed by a cationic rhodium complex of a chiral phosphine ligand having the partial formula (3), wherein n is 0 to 6 and R represents at least one non-hydrogen organic group of up to 20 C atoms.