2-[(E)-2-phenylethenyl]-5,6,7,8-tetrahydroquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[(E)-2-phenylethenyl]-5,6,7,8-tetrahydroquinoline
• 化学式: C₁₇H₁₇N
• 分子量: 235.32
• InChiKey: JRKIUVYZJXMCRM-ZRDIBKRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• 4-(2-Methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihydro-imidazole-2-thione as specific alpha2B agonist and methods of using the same
  申请人：Heidelbaugh M. Todd

  公开号：US20050075366A1

  公开（公告）日：2005-04-07

  The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha 2B adrenergic receptors in preference over alpha 2A and alpha 2C adrenergic receptors, and as such has no or only minimal cardivascular and/or sedatory activity. The compound is useful as medicament in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha 2B adrenergic receptors.

  该化学式的化合物，其中*表示一个不对称碳原子，对α2B肾上腺素受体具有特异性，优先于α2A和α2C肾上腺素受体，因此几乎没有或仅有极小的心血管和/或镇静活性。该化合物可用作哺乳动物，包括人类，治疗对α2B肾上腺素受体激动剂治疗敏感的疾病和/或缓解症状的药物。
• 4-(2-METHYL-5,6,7,8-TETRAHYDRO-QUINOLIN-7-YLMETHYL)-1,3-DIHYDRO-IMIDAZOLE-2-THIONE AS SPECIFIC ALPHA2B AGONIST AND METHODS OF USING THE SAME
  申请人：Heidelbaugh M. Todd

  公开号：US20080070945A1

  公开（公告）日：2008-03-20

  The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha 2B adrenergic receptors in preference over alpha 2A and alpha 2C adrenergic receptors, and as such has no or only minimal cardivascular and/or sedatory activity. The compound is useful as medicament in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha 2B adrenergic receptors.

  该化学式中的 * 表示对称碳原子，其化合物对α2B肾上腺素受体具有特异性，优先于α2A和α2C肾上腺素受体，因此具有极小的心血管和/或镇静作用或没有作用。该化合物可用作哺乳动物，包括人类，治疗对α2B肾上腺素受体激动剂敏感的疾病和/或缓解条件的药物。
• US7276522B2
  申请人：——

  公开号：US7276522B2

  公开（公告）日：2007-10-02
• US7569584B2
  申请人：——

  公开号：US7569584B2

  公开（公告）日：2009-08-04
• [EN] 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-THONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYLOALKYLMETHYL) IMIDAZOL-2-ONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOL-2-ONES AND RELATED COMPOUNDS<br/>[FR] 4-(CYCLOALKYLMETHYLE SUBSTITUTEES) IMIDAZOLE-2-THIONES, 4-( CYCLOALCENYLMETHYLE SUBSTITUEES) IMIDAZOLE-2-THIONES, 4-( CYLOALKYLMETHYLE SUBSTITUEES) IMIDAZOL-2-ONES, 4-(CYCLOALCENYLMETHYLE SUBSTITUEES) IMIDAZOL-2-ONES ET COMPOSES ASSOCIES
  申请人：ALLERGAN INC

  公开号：WO2006036404A1

  公开（公告）日：2006-04-06

  The compound of the formula (I) wherein the * indicates an asymmetric carbon, is specific to alpha2B adrenergic receptors in preference over alpha2A and alpha2C adrenergic receptors, and as such has no or only minimal cardivascular and/or sedatory activity.. The compound is useful as medicament in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors.