9-Aminoacridylpropranolol | 60566-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-Aminoacridylpropranolol
• 英文别名: 1-[1-(acridin-9-ylamino)propan-2-ylamino]-3-naphthalen-1-yloxypropan-2-ol
• CAS: 60566-40-7
• 化学式: C₂₉H₂₉N₃O₂
• 分子量: 451.6
• InChiKey: BXXLGOHTSBJVDR-UHFFFAOYSA-N

物化性质

• 沸点：
  717.8±60.0 °C(Predicted)
• 密度：
  1.245±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  66.4
• 氢给体数：
  3
• 氢受体数：
  5

制备方法与用途

类别：有毒物品

• 毒性分级：高毒
• 急性毒性：
  • 口服（小鼠）LD50: 227毫克/公斤
  • 皮下（小鼠）LD50: 562毫克/公斤

可燃性危险特性：

• 可燃，燃烧时会产生有毒氮氧化物烟雾

储运特性：

• 库房需通风、低温且干燥

灭火剂：

• 干粉、泡沫、砂土、二氧化碳及雾状水

文献信息

• Autophagy and phospholipidosis pathway assays
  申请人：Patton Wayne Forrest

  公开号：US20100093004A1

  公开（公告）日：2010-04-15

  Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.

  提供了用于检测和监测自噬和磷脂质沉积病的试验，包括溶酶体贮积病的进展。药物和治疗方法可以监测在溶酶体贮积病条件下的有效性。药物候选和疑似有毒物质也可以筛选对细胞、组织和器官的毒性。还提供了区分磷脂质沉积激活剂和自噬通路干扰剂的方法。
• AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS
  申请人：Enzo Life Sciences, Inc.

  公开号：EP2993476A1

  公开（公告）日：2016-03-09

  Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.

  所提供的检测方法可用于检测和监测自噬和磷脂变性，包括溶酶体贮积疾病的进展。可以监测溶酶体贮积疾病的药物和治疗方法在溶酶体贮积疾病条件下的有效性。还可以筛选候选药物和疑似毒剂对细胞、组织和器官的毒性。此外，还提供了区分磷脂酶激活剂和自噬途径扰乱剂的方法。
• US9250249B2
  申请人：——

  公开号：US9250249B2

  公开（公告）日：2016-02-02
• [EN] AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS<br/>[FR] DOSAGES DE LA VOIE DE L'AUTOPHAGIE ET DE LA PHOSPHOLIPIDOSE
  申请人：ENZO LIFE SCIENCES INC

  公开号：WO2011031330A1

  公开（公告）日：2011-03-17

  Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.