6-fluoro-7-(pyrrol-1-yl)-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | 106891-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-fluoro-7-(pyrrol-1-yl)-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 英文别名: 6-Fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-7-(pyrrol-1-yl)quinoline-3-carboxylic acid；1-cyclopropyl-6-fluoro-4-oxo-7-pyrrol-1-ylquinoline-3-carboxylic acid
• CAS: 106891-93-4
• 化学式: C₁₇H₁₃FN₂O₃
• 分子量: 312.3
• InChiKey: ISJRMOARTUIEPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  62.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 6-fluoro-7-(pyrrol-1-yl)-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylate 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成 6-fluoro-7-(pyrrol-1-yl)-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  1-substituted derivatives of

  摘要：

  本发明涉及6-氟-7-(吡咯-1-基)-1,4-二氢-4-氧喹啉-3-羧酸的新1-取代衍生物，其制备以及作为药物的应用。根据本发明，6-氟-7-(吡咯-1-基)-1,4-二氢-4-氧喹啉-3-羧酸的1-取代衍生物符合一般式I：##STR1## 其中：R代表甲基基团、2-羟乙基基团、乙烯基基团、环丙基甲基基团、丙基基团、环丙基基团、2-氟乙基基团、甲氨基基团或乙氨基基团，以及它们的生理上可接受的碱金属或碱土金属盐。它们可用作抗微生物剂，特别是作为抗菌和真菌静菌剂。

  公开号：

  US04727080A1

文献信息

• COMPOSITION COMPRISING AN ANTIBIOTIC AND MOMETASONE
  申请人：Intervet International B.V.

  公开号：EP2293778B1

  公开（公告）日：2013-09-18
• Compounds and Methods for modulating the Silencing of a Polynucleotide of Interest
  申请人：Peng Jin

  公开号：US20090306035A1

  公开（公告）日：2009-12-10

  Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an appropriate silencing element can be used to modulate (increase or decrease) the level of the polynucleotide targeted by the silencing element. Methods of using such compositions both in therapies involving RNAi-mediated suppression of gene expression, as well as, in vitro methods that allow for the targeted modulation of expression of a polynucleotide of interest are provided. Pharmaceutical or cosmetic formulations comprising such compounds and silencing elements also are disclosed. Methods for screening a compound of interest for the ability to modulate the activity of a heterologous silencing element also are provided.
• COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID
  申请人：Freehauf Keith A.

  公开号：US20100087409A1

  公开（公告）日：2010-04-08

  This invention relates to compositions (e.g., otic compositions) comprising an antibiotic (generally a quinolone or naphthyridinone), corticosteroid, and organic acid (generally a fatty acid). This invention also relates to treatment methods using such a composition, uses of such a composition to make medicaments, and therapeutic kits comprising such a composition.
• US4727080A
  申请人：——

  公开号：US4727080A

  公开（公告）日：1988-02-23
• [EN] COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID<br/>[FR] COMPOSITION COMPRENANT UN ANTIBIOTIQUE ET UN CORTICOSTÉROÏDE
  申请人：INTERVET INT BV

  公开号：WO2009147144A2

  公开（公告）日：2009-12-10

  This invention relates to compositions (e.g., otic compositions) comprising an antibiotic (generally a quinolone or naphthyridinone), corticosteroid, and organic acid (generally a fatty acid). This invention also relates to treatment methods using such a composition, uses of such a composition to make medicaments, and therapeutic kits comprising such a composition.