3,6-Acridinediamine, N-methyl- | 64457-71-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,6-Acridinediamine, N-methyl-
• 英文别名: 3-N-methylacridine-3,6-diamine
• CAS: 64457-71-2
• 化学式: C₁₄H₁₃N₃
• 分子量: 223.27
• InChiKey: WAQXSSPMNLNDTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Inhibition of tau-tau-association
  申请人：Wischik Michel Claude

  公开号：US20070191352A1

  公开（公告）日：2007-08-16

  A composition and use thereof for the prophylaxis or treatment of Alzheimer's disease, motor neurone disease, Lewy body disease, Pick's disease or progressive supranuclear palsy. The composition includes an agent which modulates or inhibits tau-tau association and which does not inhibit tau-tubulin binding. In the method the agent is administered to an individual in order to achieve the desired therapeutic effect. Preferably the agent which is administered is a phenothiazine compound.
• US8278298B2
  申请人：——

  公开号：US8278298B2

  公开（公告）日：2012-10-02
• [EN] INHIBITION OF VIRUS PROTEASE<br/>[FR] INHIBITION DE PROTÉASE VIRALE
  申请人：[en]HELMHOLTZ ZENTRUM MUENCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)

  公开号：WO2022129210A2

  公开（公告）日：2022-06-23

  The present invention relates to a composition, comprising at least one compound according to formula (I) as well as to a composition comprising at least one compound according to formula (I) and/or dimers of compounds according to formula (I) in particular for use in the treatment of diseases caused by betacoronaviruses, leishmaniasis, and trypanosomiasis.