Phenanthridinium, 3,8-diamino-5-(3-aminopropyl)-6-phenyl- | 68613-49-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Phenanthridinium, 3,8-diamino-5-(3-aminopropyl)-6-phenyl-
• 英文别名: 5-(3-aminopropyl)-6-phenylphenanthridin-5-ium-3,8-diamine
• CAS: 68613-49-0
• 化学式: C22H23N4+
• 分子量: 343.4
• InChiKey: FIGLWEWGRHTXKJ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  81.9
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Reversible Hydrophobic Modification of Drugs for Improved Delivery to Cells
  申请人：Monahan Sean D.

  公开号：US20090074885A1

  公开（公告）日：2009-03-19

  Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytically labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells are described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.