8-Quinolinecarboxylic acid, phenylmethyl ester | 134959-55-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Quinolinecarboxylic acid, phenylmethyl ester
• 英文别名: benzyl quinoline-8-carboxylate
• CAS: 134959-55-0
• 化学式: C₁₇H₁₃NO₂
• 分子量: 263.29
• InChiKey: ZKCLHWMJUNNHHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] DIFLUOROHALOALLYLAMINE SULFONE DERIVATIVE INHIBITORS OF LYSYL OXIDASES, METHODS OF PREPARATION, AND USES THEREOF<br/>[FR] INHIBITEURS DE DÉRIVÉ DE DIFLUOROHALOALLYLAMINE SULFONE DE LYSYL OXYDASES, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS UTILISATIONS
  申请人：PHARMAXIS LTD

  公开号：WO2021012014A1

  公开（公告）日：2021-01-28

  The present invention relates to methods for preparing a variety of difluorohaloallylamine derivatives. The present invention also relates to novel difluorohaloallylamine derivatives that are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for the treatment of a variety of indications, e.g., fibrosis, cancer and/or scarring in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as uses thereof.