(2R)-2-benzyl-3-(4-methoxyphenyl)propanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (2R)-2-benzyl-3-(4-methoxyphenyl)propanoic acid
• 化学式: C₁₇H₁₈O₃
• 分子量: 270.328
• InChiKey: HMLWWSKYXBGOMT-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.18
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (2R)-2-benzyl-3-(4-methoxyphenyl)propanoic acid 、 (+)-camphorsultam 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 39.0h， 生成
  参考文献：
  名称：

  Asymmetric synthesis of α-chiral dihydrocinnamates by catalytic reductive aldol coupling and subsequent dehydroxylation

  摘要：

  Optically active dihydrocinnamate derivatives bearing the chiral carbon center at a-position were synthesized by Rh(Phebox)-catalyzed asymmetric reductive aldol coupling reaction with substituted cinnamates and benzaldehyde derivatives and subsequent dehydroxylation reaction. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.10.055
• 作为产物：
  描述：

  在 sodium chlorite 、 sodium dihydrogenphosphate 、 2-甲基-2-丁烯 作用下， 以 水 、 叔丁醇 为溶剂， 反应 26.0h， 生成 (2R)-2-benzyl-3-(4-methoxyphenyl)propanoic acid
  参考文献：
  名称：

  Asymmetric synthesis of α-chiral dihydrocinnamates by catalytic reductive aldol coupling and subsequent dehydroxylation

  摘要：

  Optically active dihydrocinnamate derivatives bearing the chiral carbon center at a-position were synthesized by Rh(Phebox)-catalyzed asymmetric reductive aldol coupling reaction with substituted cinnamates and benzaldehyde derivatives and subsequent dehydroxylation reaction. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.10.055

文献信息

• Asymmetric synthesis of α-chiral dihydrocinnamates by catalytic reductive aldol coupling and subsequent dehydroxylation
  作者：Toru Hashimoto、Takushi Shiomi、Jun-ichi Ito、Hisao Nishiyama

  DOI：10.1016/j.tet.2007.10.055

  日期：2007.12

  Optically active dihydrocinnamate derivatives bearing the chiral carbon center at a-position were synthesized by Rh(Phebox)-catalyzed asymmetric reductive aldol coupling reaction with substituted cinnamates and benzaldehyde derivatives and subsequent dehydroxylation reaction. (c) 2007 Elsevier Ltd. All rights reserved.