5-(4-Hydroxyphenyl)-1-isopropylimidazole | 76134-12-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-Hydroxyphenyl)-1-isopropylimidazole
• 英文别名: 4-(1-isopropyl-1H-imidazol-5-yl)phenol；4-(3-Propan-2-ylimidazol-4-yl)phenol
• CAS: 76134-12-8
• 化学式: C₁₂H₁₄N₂O
• 分子量: 202.256
• InChiKey: UDQGNUZUOPEHLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯化苄 、 5-(4-Hydroxyphenyl)-1-isopropylimidazole 在 sodium hydride 作用下， 生成 5-(4-Benzyloxyphenyl)-1-isopropylimidazole
  参考文献：
  名称：

  Yamada, Naotaka; Kuwano, Eiichi; Kikuchi, Masamichi, Bioscience, Biotechnology and Biochemistry, 1992, vol. 56, # 12, p. 1943 - 1948

  摘要：

  DOI：
• 作为产物：
  描述：

  N--2-amino-propan 、 对甲基苯磺酰甲基异腈 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 5-(4-Hydroxyphenyl)-1-isopropylimidazole
  参考文献：
  名称：

  Kuwano, Eiichi; Hisano, Tomomi; Eto, Morifusa, Agricultural and Biological Chemistry, 1991, vol. 55, # 12, p. 2999 - 3004

  摘要：

  DOI：

文献信息

• DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS
  申请人：BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

  公开号：US20150175582A1

  公开（公告）日：2015-06-25

  Antibacterial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit or parasite or bacterial growth.

  本文描述了抗菌IspF抑制剂化合物和组合物。方法包括给予所述化合物和组合物以治疗细菌或寄生虫感染并抑制寄生虫或细菌的生长。
• DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS (ISPF)
  申请人：BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

  公开号：US20160257655A1

  公开（公告）日：2016-09-08

  Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit parasite or bacterial growth.

  本文描述了抗菌和抗疟疾的IspF抑制剂化合物和组合物。方法包括给予所述化合物和组合物以治疗细菌或寄生虫感染并抑制寄生虫或细菌的生长。
• Heterocyclic derivatives of (4-aryloxymethyl-1.3-dioxolan-2-yl) methyl-1H-imidazoles and -1H-1.2.4-triazoles, their preparation and the derivatives for use as fungicides and bactericides
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0006712A1

  公开（公告）日：1980-01-09

  Compounds having the formula: and the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein: Q is a member selected from the group consisting of CH and N; Ar is a member selected from the group consisting of thienyl, halothienyl, phenyl and substituted phenyl; and Y is a member selected from the group consisting of optionally substituted pyrimidinyl, imidazolyl, oxazolyl, thiazolyl, pyrazolyl, isoxazolyl and oxadiazolyl. The compounds are useful as antifungal and antibacterial agents.

  具有以下式子的化合物 及其药学上可接受的酸加成盐和立体化学异构体，其中 Q 是选自 CH 和 N 组成的组的成员； Ar 是选自噻吩基、卤代噻吩基、苯基和取代苯基的成员；以及 Y 选自任选取代的嘧啶基、咪唑基、噁唑基、噻唑基、吡唑基、异噁唑基和噁二唑基组成的组。 这些化合物可用作抗真菌剂和抗菌剂。
• Amaranzole A, a New <i>N</i>-Imidazolyl Steroid from <i>Phorbas amaranthus</i>
  作者：Brandon I. Morinaka、Makoto N. Masuno、Joseph R. Pawlik、Tadeusz F. Molinski

  DOI：10.1021/ol702325e

  日期：2007.12.1

  An unprecedented 24-N-imidazolyl steroidal alkaloid, amaranzole A, was isolated from a tropical sponge, Phorbas amaranthus. The structure was solved by interpretation of MS, NMR, including a novel exciton-coupled CD spectrum due to an allyl imidazole, and comparison with model compounds.
• US4218458A
  申请人：——

  公开号：US4218458A

  公开（公告）日：1980-08-19