3-Ethyl-2-[3-(1-ethylquinolin-1-ium-4-yl)prop-2-enylidene]-1,3-benzothiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-Ethyl-2-[3-(1-ethylquinolin-1-ium-4-yl)prop-2-enylidene]-1,3-benzothiazole
• 化学式: C23H23N2S+
• 分子量: 359.5
• InChiKey: DJAQPUXEDANWNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  32.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• ASYMMETRIC CYANINE FLUORESCENT DYES
  申请人：Peng Xiaojun

  公开号：US20090017441A1

  公开（公告）日：2009-01-15

  The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R 1 , R 2 , R 3 , R 4 , R 5 and Y − are as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods for staining biological samples using the fluorescent dyes and compositions thereof.

  本公开提供了式I中的不对称青霉素荧光染料，其中X、n、R1、R2、R3、R4、R5和Y-如规范中所定义。本公开还提供了荧光染料的结合物，其制备方法，包含荧光染料的组合物，以及使用荧光染料和其组合物对生物样本进行染色的方法。
• MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20160018389A1

  公开（公告）日：2016-01-21

  An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

  本发明的一个目的是提供一种利用有机化合物对巨噬细胞亚型进行识别的方法。本发明的另一个目的是提供一种巨噬细胞识别试剂，其中当添加有机化合物时得到的光谱特征取决于巨噬细胞亚型而不同。本发明的另一个目的是提供一种利用巨噬细胞识别试剂进行巨噬细胞亚型评估的方法，一种用于巨噬细胞亚型与测试物之间相关性分析的方法，一种用于巨噬细胞亚型与测试物之间相关性筛选的方法，以及一种试剂盒。提供了一种利用添加有机化合物得到的光谱特征不同取决于巨噬细胞亚型的巨噬细胞亚型识别方法。
• Reagent for analyzing urine and method for analyzing urine
  申请人：SYSMEX CORPORATION

  公开号：EP1837402A1

  公开（公告）日：2007-09-26

  A reagent for analyzing urine is described. The reagent comprises a fungus membrane damaging agent for damaging a cellular membrane of yeast-like fungus in urine; a first dye for staining yeast-like fungus so that a fluorescent intensity of damaged yeast-like fungus becomes more intense than that of erythrocyte in urine; and a second dye for staining sperm in urine so that a fluorescent intensity of sperm becomes more intense than that of the damaged yeast-like fungus.

  描述了一种用于分析尿液的试剂。该试剂包括：用于破坏尿液中酵母样真菌细胞膜的真菌膜破坏剂；用于染色酵母样真菌的第一种染料，使受损酵母样真菌的荧光强度比尿液中红细胞的荧光强度更强；以及用于染色尿液中精子的第二种染料，使精子的荧光强度比受损酵母样真菌的荧光强度更强。
• REAGENT AND REAGENT KIT FOR ANALYSIS OF PRIMITIVE LEUKOCYTE
  申请人：Sysmex Corporation

  公开号：EP2166354A1

  公开（公告）日：2010-03-24

  The present invention provides a reagent for analysis of immature leukocytes comprising: a surfactant which can damage cell membranes of erythrocytes and mature leukocytes, a solubilizing agent which can shrink the damaged blood cells and at least one dye for staining nucleic acid selected from the dyes of the formulae (I) and (II), wherein X- is an anion.

  本发明提供了一种用于分析未成熟白细胞的试剂，包括 一种表面活性剂，可破坏红细胞和成熟白细胞的细胞膜、 可使受损血细胞缩小的增溶剂，以及 至少一种用于染色核酸的染料，选自式 (I) 和 (II) 染料，其中 X- 是阴离子。
• Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent
  申请人：CANON KABUSHIKI KAISHA

  公开号：US10041937B2

  公开（公告）日：2018-08-07

  An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

  本发明的一个目的是提供一种利用有机化合物识别巨噬细胞亚型的方法。本发明的另一个目的是提供一种含有有机化合物的巨噬细胞识别剂，其中添加有机化合物时获得的光谱特性因巨噬细胞亚型的不同而不同。本发明的另一个目的是提供一种使用巨噬细胞鉴定剂的巨噬细胞亚型的评估方法、巨噬细胞亚型与测试物质之间相关性的分析方法、巨噬细胞亚型与测试物质之间相关性的筛选方法和试剂盒。本发明提供了一种巨噬细胞亚型的鉴别方法，该方法利用了添加有机化合物后获得的光谱特性随巨噬细胞亚型的不同而不同的特点。