4-(9-Chloro-10-phenyl-9,10-dihydroacridin-9-YL)-N,N-diethylaniline hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(9-Chloro-10-phenyl-9,10-dihydroacridin-9-YL)-N,N-diethylaniline hydrochloride
• 英文别名: 4-(9-chloro-10-phenylacridin-9-yl)-N,N-diethylaniline;hydrochloride
• 化学式: C29H28Cl2N2
• 分子量: 475.4
• InChiKey: BMZMDKQYNJFFOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.27
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  6.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Enrichment and selective culture of mycobacteria
  申请人：BIOMERIEUX

  公开号：US10597693B2

  公开（公告）日：2020-03-24

  A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a culture medium including a nutritive component suitable for the development and growth of mycobacteria, wherein the culture medium includes, as selective agents, at least 9-chloro-9-(4′-diethylamino)phenyl-9,10-dihydro-10-phenylacridine hydrochloride (or C-390) and an agent capable of inhibiting Pseudomonas aeruginosa bacteria. The invention also relates to a culture medium suitable for implementing this process for the enrichment and selective culture of mycobacteria.

  一种对生物样品中所含分枝杆菌进行富集和选择性培养的工艺，其中将全部或部分样品接种在包括适于分枝杆菌发育和生长的营养成分的培养基中/上、其中培养基作为选择剂至少包括 9-氯-9-(4′-二乙氨基)苯基-9,10-二氢-10-苯基吖啶盐酸盐(或 C-390)和一种能抑制绿脓杆菌的制剂。本发明还涉及一种适用于实施该工艺的培养基，用于分枝杆菌的富集和选择性培养。
• RAPID DETECTION OF METABOLIC ACTIVITY
  申请人：Spectral Platforms, Inc.

  公开号：EP2748588A1

  公开（公告）日：2014-07-02
• ENRICHISSEMENT ET CULTURE SÉLECTIVE DE MYCOBACTÉRIES
  申请人：bioMérieux

  公开号：EP3253885B1

  公开（公告）日：2019-01-02
• ENRICHMENT AND SELECTIVE CULTURE OF MYCOBACTERIA
  申请人：BIOMERIEUX

  公开号：US20180030500A1

  公开（公告）日：2018-02-01

  A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a culture medium including a nutritive component suitable for the development and growth of mycobacteria, wherein the culture medium includes, as selective agents, at least 9-chloro-9-(4′-diethylamino)phenyl-9,10-dihydro-10-phenylacridine hydrochloride (or C-390) and an agent capable of inhibiting Pseudomonas aeruginosa bacteria. The invention also relates to a culture medium suitable for implementing this process for the enrichment and selective culture of mycobacteria.
• [EN] RAPID DETECTION OF METABOLIC ACTIVITY<br/>[FR] DÉTECTION RAPIDE D'ACTIVITÉ MÉTABOLIQUE
  申请人：SPECTRAL PLATFORMS INC

  公开号：WO2013028706A1

  公开（公告）日：2013-02-28

  Some aspects of the invention provide for a method for detecting metabolic activity in a sample by obtaining a sample, illuminating the sample at a plurality of time points, measuring transmitted light from a marker of metabolic activity in the sample at the plurality of time points, and detecting the presence or absence of metabolic activity from a change in the transmitted light at the plurality of time points. Other aspects of the invention provide for a method for detecting metabolic activity in a sample by providing a sample have a detectable marker therein that is reflective of metabolic activity in the sample, producing an amplified signal from the marker, measuring the amplified signal at a plurality of time points, and detecting metabolic activity from a change in the signal. Additional aspects provide for a system for detecting metabolic activity in a sample.