[2-(2-{2-[2-(2-氨基-乙氧基)-乙氧基]-乙氧基}-乙氧基)-乙氧基]乙酸 | 141282-35-1

• 物质功能分类: 催化剂及助剂 - 聚合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: [2-(2-{2-[2-(2-氨基-乙氧基)-乙氧基]-乙氧基}-乙氧基)-乙氧基]乙酸
• 中文别名: 氨基-六聚乙二醇-羧酸
• 英文名称: [2-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]acetic acid
• 英文别名: Amino-PEG5-CH2CO2H；2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• CAS: 141282-35-1
• 化学式: C₁₂H₂₅NO₇
• 分子量: 295.333
• InChiKey: ZQGSSZVORHCAFC-UHFFFAOYSA-N

物化性质

• 沸点：
  434.2±40.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO：20 mg/mL（67.72 mM；超声加热并加热至 60°C）

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [2-(2-{2-[2-(2-氨基-乙氧基)-乙氧基]-乙氧基}-乙氧基)-乙氧基]乙酸 、 tert-butyl 2-(2-formyl-1H-imidazol-1-yl)acetate 在 sodium triacetoxyborohydride 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 13.5h， 以84%的产率得到
  参考文献：
  名称：

  A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using ^99mTc- and ¹⁷⁷Lu-Labeled Tetrazines

  摘要：

  A high yield synthesis of a novel, small molecule, bisphosphonate-modified trans-cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and captures functionalized tetrazines in vivo, via the bioorthogonal inverse electron demand Diels-Alder (IEDDA) cycloaddition, was developed. A Tc-99m-labeled derivative of 2 demonstrated selective localization to shoulder and knee joints in a biodistribution study in normal mice. Compound 2 reacted rapidly with a Lu-177-labeled tetrazine in vitro, and pretargeting experiments in mice, using 2 and the Lu-177-labeled tetrazine, yielded high activity concentrations in shoulder and knee joints, with minimal uptake in other tissues. Pretargeting experiments with 2 and a novel Tc-99m-labeled tetrazine also produced high activity concentrations in the knees and shoulders. Critically, both radiolabeled tetrazines showed negligible uptake in the skeleton and joints when administered in the absence of 2. Compound 2 can be utilized to target functionalized tetrazines to bone and represents a convenient reagent to test novel tetrazines for use with in vivo bioorthogonal pretargeting strategies.

  DOI：

  10.1021/acs.jmedchem.6b00938
• 作为产物：
  描述：

  tert-butyl 17-azido-3,6,9,12,15-pentaoxaheptadecanoate 在 氨 、 水 、 三苯基膦 、 potassium hydroxide 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 生成 [2-(2-{2-[2-(2-氨基-乙氧基)-乙氧基]-乙氧基}-乙氧基)-乙氧基]乙酸
  参考文献：
  名称：

  轻松获得18-crown-6中的不对称取代的低聚乙二醇

  摘要：

  据报道，基于18-crown-6的脱环作用，制备了多克量的异双功能低聚乙二醇（OEG）衍生物（n  = 6、7 ）的新途径。

  DOI：

  10.1016/j.tetlet.2013.06.065
• 作为试剂：
  描述：

  [2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]acetic acid benzyl ester 、 在 钯 甲醇 、 [2-(2-{2-[2-(2-氨基-乙氧基)-乙氧基]-乙氧基}-乙氧基)-乙氧基]乙酸 作用下， 以 甲醇 为溶剂， 反应 2.5h， 以to yield the desired [2-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]acetic acid (Compound 7; 1.4 g, quantitative)的产率得到[2-(2-{2-[2-(2-氨基-乙氧基)-乙氧基]-乙氧基}-乙氧基)-乙氧基]乙酸
  参考文献：
  名称：

  Method of inhibiting nonspecific interaction between molecules on solid phase support

  摘要：

  本发明提供了一种抑制分子间非特异性相互作用的方法，其特征在于，在将分子固定在固相载体上并分析与固相上与分子特异性相互作用的分子之间的特定相互作用的过程中，调节固相载体中固相表面的疏水性质，特别是在将分子固定在固相载体上时夹层加入亲水性的间隔物，该方法使得能够抑制分子间的非特异性相互作用，并减少对固相的非特异性吸附。

  公开号：

  US07919653B2

文献信息

• Target specific antibody-superantigen conjugates and their preparation
  申请人：Pharmacia & Upjohn AB

  公开号：US05858363A1

  公开（公告）日：1999-01-12

  A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regime for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.

  一种可溶性抗体偶联物，包括将抗体与可被T细胞识别的结构连接起来，该结构具有引导T细胞杀伤被抗体识别的靶细胞的能力。该偶联物的特点是结构为超抗原。其中一种重要的模式是一种用于溶解靶细胞的方法，其中将靶细胞与足够量的偶联物接触。该溶解方法是治疗癌症、自身免疫、寄生虫感染以及真菌、病毒和细菌感染的强效治疗方案的一部分。该说明书还描述了合成偶联物和制药组合物及其制造的模式。
• Antibody conjugates
  申请人：Pharmacia & Upjohn AB

  公开号：US06197299B1

  公开（公告）日：2001-03-06

  A soluble antibody conjugate comprising an antibody linked to a structure which is recognized by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regime for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.

  一种可溶性抗体共轭物，包括与T细胞识别的结构物相连的抗体，具有将T细胞引导到溶解被抗体识别的靶细胞的能力。该共轭物的特征在于结构物为超抗原。一种重要的模式是靶细胞溶解的方法，其中靶细胞与共轭物的靶细胞溶解有效量接触。该裂解方法是针对癌症、自身免疫、寄生虫感染和真菌、病毒和细菌感染的强效治疗方案的一部分。该说明书还描述了合成共轭物和制药组合物及其制造的模式。
• Method for Suppressing Intermolecular Nonspecific Interaction and for Intensifying Intermolecular Specific Interaction on Metal Surface
  申请人：Tanaka Akito

  公开号：US20080176341A1

  公开（公告）日：2008-07-24

  The present invention provides a method of searching for a target molecule for a ligand immobilized on a metal surface or analyzing the interaction between a ligand and a target molecule, characterized in that the immobilization of the ligand on the metal surface via a hydrophilic spacers, and the method eliminates or suppresses a nonspecific interaction that prevents analysis of intermolecular interaction on a metal surface, and can intensify specific intermolecular interactions.

  本发明提供了一种寻找固定在金属表面上的配体的靶分子或分析配体与靶分子之间相互作用的方法。其特征在于，通过亲水性间隔物将配体固定在金属表面上，该方法消除或抑制了阻止在金属表面上分析分子间相互作用的非特异性相互作用，并能增强特异性分子间相互作用。
• SERIES OF HALOGENATED TETRACYCLIC TRITERPENE DERIVATIVES AND THEIR PREPARATION AND APPLICATION
  申请人：SHANGHAI KING-X BIOTECH CO., LTD

  公开号：US20220177511A1

  公开（公告）日：2022-06-09

  The invention provides a series of halogenated tetracyclic triterpene derivatives and their preparation and application. It is represented by the following general structural formula: R 1 is halogen, R 2 is H, and the halogen is selected from fluorine, chlorine, bromine or iodine; or R 1 and R 2 are each fluorine, and R 3 is an amine, alcohol, amino acid, peptide or phosphate linked to oxygen through an acyl group. The derivatives are relatively stable in rat whole blood through pharmacokinetic studies. The absolute bioavailability after a single intragastric administration for male and female rats was 15.6% and 28.4% respectively. The mean bioavailability was 22%. The derivatives showed better in vivo activities compared with the existing standard drugs enalapril and sacubitril valsartan sodium. Meanwhile, hydrophilic prodrugs of the tetracyclic triterpenoid derivatives in the present invention were prepared. The derivatives of the present invention can be used for preparing cardiovascular medicines.

  本发明提供了一系列卤代四环三萜衍生物及其制备和应用。其通式如下：R1为卤素，R2为氢，卤素选自氟、氯、溴或碘；或R1和R2均为氟，R3为胺、醇、氨基酸、肽或磷酸，通过酰基连接到氧。通过药代动力学研究，这些衍生物在大鼠全血中相对稳定。单次口服给雄性和雌性大鼠后的绝对生物利用度分别为15.6％和28.4％。平均生物利用度为22％。与现有标准药物依那普利和沙库巴曲钠相比，这些衍生物在体内活性更好。同时，本发明还制备了四环三萜衍生物的亲水性前药。本发明的衍生物可用于制备心血管药物。
• METHOD OF INHIBITING NONSPECIFIC INTERACTION BETWEEN MOLECULES ON SOLID PHASE SUPPORT
  申请人：Reverse Proteomics Research Institute Co., Ltd

  公开号：EP1553412A1

  公开（公告）日：2005-07-13

  The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.

  本发明提供了一种抑制分子间非特异性相互作用的方法，其特征在于，在将分子固定在固相载体上并分析该分子与固相上与该分子特异性相互作用的分子之间的特异性相互作用的过程中、调节固相载体中固相表面的疏水性，特别是在将分子固定到固相载体上时，在固相载体中插入亲水间隔物，这种方法可以抑制分子之间的非特异性相互作用，减少对固相的非特异性吸附。