3-hydroxy-hex-5-yn-2-one | 40797-89-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-hydroxy-hex-5-yn-2-one
• 英文别名: 3-hydroxy-5-hexyn-2-one；3-hydroxyhex-5-yn-2-one
• CAS: 40797-89-5
• 化学式: C₆H₈O₂
• 分子量: 112.128
• InChiKey: CSVQCBXDXHVMAS-UHFFFAOYSA-N

物化性质

• 沸点：
  226.9±20.0 °C(Predicted)
• 密度：
  1.054±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-hydroxy-hex-5-yn-2-one 、 对甲苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-tosyloxy-5-hexyn-2-one
  参考文献：
  名称：

  Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers

  摘要：

  提供了一些在溃疡治疗中有用的咪唑并[1,2-a]杂环化合物。

  公开号：

  US04725601A1
• 作为产物：
  描述：

  3-Hydroxy-2-methoxyhex-1-en-5-in 在 硫酸 作用下， 生成 3-hydroxy-hex-5-yn-2-one
  参考文献：
  名称：

  Synthesis of 2-Oxo-3-hydroxy-Δ⁴-alkenes (Unsaturated Acyloins)

  摘要：

  DOI：

  10.1055/s-1973-22138

文献信息

• Imidazopyridine compounds useful in the treatment of ulcers
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04782055A1

  公开（公告）日：1988-11-01

  The present invention relates to imidazopyridine compounds of the formula: ##STR1## wherein R.sup.1 is lower alkynyl or lower alkynyloxy(lower)-alkyl, R.sup.2 is lower alkyl, and R.sup.3 is ar(lower)alkyl having lower alkoxy, lower alkylthio, nitro or lower alkanesulfonyl, ar(lower)alkyl having nitro and one or two additional substituent(s) selected from nitro and lower alkyl, or heterocyclic(lower)alkyl which may have suitable substituent(s), and to their utility. The compounds have antiulcerative properties.

  本发明涉及一种式为：##STR1##其中R.sup.1为较低的炔基或较低的炔氧（较低）-烷基，R.sup.2为较低的烷基，R.sup.3为具有较低的烷氧基，较低的烷基硫基，硝基或较低的烷基磺酰基的芳基（较低）-烷基，具有硝基和一或两个额外取代基（从硝基和较低的烷基中选择）的芳基（较低）-烷基，或者具有适当的取代基的杂环（较低）-烷基，以及它们的用途。这些化合物具有抗溃疡性能。
• Imidazopyridine compounds and processes for preparation thereof
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0228006A1

  公开（公告）日：1987-07-08

  An imidazopyridine compound of the formula: wherein R1 is lower alkynyl or lower alkynyloxy-(lower)alkyl, R2 is lower alkyl, and R3 is ar(lower)alkyl having lower alkoxy, lower alkylthio, nitro or lower alkanesulfonyl, ar(lower)alkyl having nitro and one or two additional substituent(s) selected from nitro and lower alkyl, or heterocyclic(lower)alkyl which may have suitable substituent(s), and a pharmaceutically acceptable salt thereof, processes for the preparation thereof and pharmaceutical compositions comprising such compounds in admixture with pharmaceutically acceptable carriers.

  式中的咪唑吡啶化合物： 其中 R1 是低级炔基或低级炔氧基-（低级）烷基、 R2 是低级烷基，以及 R3是具有低级烷氧基、低级硫代烷基、硝基或低级烷磺酰基的低级烷基，具有硝基和一个或两个选自硝基和低级烷基的取代基的低级烷基，或具有适当取代基的杂环低级烷基，以及其药学上可接受的盐、其制备工艺和包含这种化合物与药学上可接受的载体混合的药物组合物。
• Imidazoheterocyclic compounds processes for preparation thereof and pharmaceutical compositions comprising them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0204285B1

  公开（公告）日：1992-01-15
• Process for Preparing Cyclic Esters Comprising Unsaturated Functional Groups and Polyesters Prepared From Same
  申请人：Markland Peter

  公开号：US20120004324A1

  公开（公告）日：2012-01-05

  Disclosed herein are process for preparing cyclic esters comprising unsaturated functional groups. Also disclosed are copolymers prepared from the cyclic esters. The copolymers can be used to form microparticles, polymer micelles, etc., which are useful in drug delivery applications.
• Process for Preparing Cyclic Esters Comprising Unsaturated Functional groups And Polyesters Prepared From Same
  申请人：Markland Peter

  公开号：US20130171261A1

  公开（公告）日：2013-07-04

  Disclosed herein are process for preparing cyclic esters comprising unsaturated functional groups. Also disclosed are copolymers prepared from the cyclic esters. The copolymers can be used to form microparticles, polymer micelles, etc., which are useful in drug delivery applications.