(1R)-2-methyl-1-quinolin-3-ylpropan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (1R)-2-methyl-1-quinolin-3-ylpropan-1-amine
• 化学式: C₁₃H₁₆N₂
• 分子量: 200.28
• InChiKey: GTOQWXIKOAMLDA-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• P2X3 and/or P2X2/3 compounds and methods
  申请人：Asana BioSciences, LLC

  公开号：US10174039B2

  公开（公告）日：2019-01-08

  The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

  本公开提供了新型化合物以及制备和使用这些化合物的方法。在一个实施方案中，这些化合物具有式（I）的结构，其中 R1-R7 在此定义。在另一个实施方案中，这些化合物可用于调节 P2X3 或 P2X2/3 受体中的一种或两种。在另一个实施方案中，通过给患者施用一种或多种化合物，这些化合物可用于治疗患者的疼痛。在另一个实施方案中，通过向患者施用一种或多种化合物，这些化合物可用于治疗患者的呼吸功能障碍。
• P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
  申请人：Asana BioSciences, LLC

  公开号：US20180093991A1

  公开（公告）日：2018-04-05

  The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R 1 -R 7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X 3 or P2X 2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.