(2E)-1-{2-methyl-4-[2-(piperidin-1-yl)ethyl]-4H-pyrazolo[1,5-a]benzimidazol-3-yl}-3-(4-nitrophenyl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2E)-1-{2-methyl-4-[2-(piperidin-1-yl)ethyl]-4H-pyrazolo[1,5-a]benzimidazol-3-yl}-3-(4-nitrophenyl)prop-2-en-1-one
• 英文别名: (E)-1-[2-methyl-4-(2-piperidin-1-ylethyl)pyrazolo[1,5-a]benzimidazol-3-yl]-3-(4-nitrophenyl)prop-2-en-1-one
• 化学式: C26H27N5O3
• 分子量: 457.5
• InChiKey: BMQYULFPSLMHGJ-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  88.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PYRROLO[2,3-B]PYRIDIN DERIVATIVES AS INHIBITORS OF INFLUENZA VIRUS REPLICATION
  申请人：COCRYSTAL PHARMA, INC.

  公开号：US20210121462A1

  公开（公告）日：2021-04-29

  Provided herein are compounds of Formula A, B or C that can inhibit the replication of influenza viruses, reduce the amount of influenza viruses, and/or treat influenza.
• INHIBITORS OF INFLUENZA VIRUS REPLICATION
  申请人：COCRYSTAL PHARMA, INC.

  公开号：US20220048897A1

  公开（公告）日：2022-02-17

  Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient a safe and effective amount of a compound represented by Formula I, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a safe and effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
• PYRIDOPYRAZINE AND PYRIDOTRIAZINE INHIBITORS OF INFLUENZA VIRUS REPLICATION
  申请人：COCRYSTAL PHARMA, INC.

  公开号：US20220056024A1

  公开（公告）日：2022-02-24

  Provided herein are compounds that can inhibit the replication of influenza viruses, reduce the amount of influenza viruses, and/or treat influenza. (I)