Ethyl 3-(3-chloro-4-methoxyphenyl)-2-cyanoacrylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Ethyl 3-(3-chloro-4-methoxyphenyl)-2-cyanoacrylate
• 英文别名: ethyl (E)-3-(3-chloro-4-methoxyphenyl)-2-cyanoprop-2-enoate
• 化学式: C₁₃H₁₂ClNO₃
• 分子量: 265.69
• InChiKey: JSERVOZFIJGGMZ-UXBLZVDNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  59.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Application of ethyl p-methoxycinnamate and derivatives thereof in maintaining self-renewal and pluripotency of stem cells
  申请人：NORTHEAST NORMAL UNIVERSITY

  公开号：US10723998B2

  公开（公告）日：2020-07-28

  Disclosed is a use of ethyl p-methoxycinnamate and derivatives thereof in preparing drugs, culture media, regulating agents or cosmetic and skin caring products for maintaining self-renewal and pluripotency of stem cells. The stem cells comprise adult stem cells, embryonic stem cells and induced pluripotent stem (iPS) cells. Also disclosed is a use of ethyl p-methoxycinnamate and the derivatives thereof in in-vitro amplification of stem cells and preparation of induced pluripotent stem (iPS) cells and a use of ethyl p-methoxycinnamate and the derivatives thereof in preparing drugs for treating cell deletion or injury diseases.

  本发明公开了对甲氧基肉桂酸乙酯及其衍生物在制备药物、培养基、调节剂或美容护肤产品中的用途，用于维持干细胞的自我更新和多能性。干细胞包括成体干细胞、胚胎干细胞和诱导多能干细胞（iPS）。还公开了对甲氧基肉桂酸乙酯及其衍生物在体外扩增干细胞和制备诱导多能干（iPS）细胞中的用途，以及对甲氧基肉桂酸乙酯及其衍生物在制备治疗细胞缺失或损伤疾病药物中的用途。
• Surface treatment by photopolymerisation to obtain biocidal properties
  申请人：Perichaud Alain

  公开号：US20050095266A1

  公开（公告）日：2005-05-05

  The present invention relates to a process for surface treatment of a solid substrate in which photopolymerisation and covalent grafting are performed in situ on said substrate of a biocidal copolymer, wherein steps are taken in which: a) said solid substrate is put in contact with a formulation comprising: 1—at least one monomer comprising a biocidal group, 2—at least one copolymerisable compound with said biocidal monomer comprising a multifunctional monomer or oligomer mono- di- or selected amongst acrylate, epoxide or vinyl ether monomers or oligomers, 3—at least one photoprimer selected amongst radical and/or cationic photoprimers, and 4—at least one grafting agent on said substrate, and b) photocopolymerisation and covalent grafting of the copolymers obtained are carried into effect by subjecting said formulation in contact with said solid substrate to ultraviolet radiation.

  本发明涉及一种对固体基材进行表面处理的工艺，在该工艺中，在所述基材上对杀菌共聚物进行原位光聚合和共价接枝，其中采取的步骤包括：a) 将所述固体基材与一种配方接触，该配方包括：1-至少一种包含杀菌基团的单体，2-至少一种可与所述杀菌单体共聚的化合物，该化合物包含多功能单体或低聚物，单-二-或低聚物：1- 至少一种含有杀菌基团的单体； 2- 至少一种可与所述杀菌单体共聚的化合物，包括多功能单体或低聚物，单-双-或从丙烯酸酯、环氧化物或乙烯基醚单体或低聚物中选择、3- 至少一种从自由基和/或阳离子光聚合物中选出的光聚合物，以及 4- 至少一种在所述基底上的接枝剂，以及 b) 通过将与所述固体基底接触的配方置于紫外线辐射下，实现所获得共聚物的光聚合和共价接枝。
• COMPOSITION AUTO-REPARANTE. MATERIAUX A AUTO-REPARATION PROCEDES D' AUTOREPARATION ET APPLICATIONS
  申请人：Catalyse

  公开号：EP2242774B1

  公开（公告）日：2013-01-09
• SELF-REPAIRING COMPOSITION, SELF-REPAIRING MATERIALS, SELF-REPAIRING METHODS AND APPLICATIONS
  申请人：Perichaud Alain

  公开号：US20110057340A1

  公开（公告）日：2011-03-10

  The invention relates to a micro-encapsulated self-repairing polymerizable composition that comprises at least one selected polymerizable compound to be integrated into organic, inorganic or composite materials for the self-repairing of damages incurred in the use conditions thereof, characterised in that micro-encapsulated polymerizable composition is integrated alone into said materials and, after the release of the microcapsule and in the absence of a catalyst, spontaneously polymerises in the presence of a polymerisation-triggering agent that is absent in said materials but naturally occurs during the use thereof, thus repairing said damages.
• SURFACE TREATMENT BY PHOTOPOLYMERISATION TO OBTAIN BIOCIDAL PROPERTIES
  申请人：PERICHAUD Alain

  公开号：US20120202912A1

  公开（公告）日：2012-08-09

  The present invention relates to a process for surface treatment of a solid substrate in which photopolymerisation and covalent grafting are performed in situ on said substrate of a biocidal copolymer, wherein steps are taken in which: a) said solid substrate is put in contact with a formulation comprising: 1—at least one monomer comprising a biocidal group, 2—at least one copolymerisable compound with said biocidal monomer comprising a multifunctional monomer or oligomer mono- di- or selected amongst acrylate, epoxide or vinyl ether monomers or oligomers, 3—at least one photoprimer selected amongst radical and/or cationic photoprimers, and 4—at least one grafting agent on said substrate, and b) photocopolymerisation and covalent grafting of the copolymers obtained are carried into effect by subjecting said formulation in contact with said solid substrate to ultraviolet radiation.