Indolylglucosinolate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Indolylglucosinolate
• 英文别名: [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1E)-2-(1H-indol-3-yl)-N-sulfooxyethanimidothioate
• 化学式: C₁₆H₂₀N₂O₉S₂
• 分子量: 448.5
• InChiKey: DNDNWOWHUWNBCK-NMIPTCLMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  216
• 氢给体数：
  6
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  Indolylglucosinolate 生成 吲哚-3-乙腈
  参考文献：
  名称：

  HANLEY, A. BRYAN;PARSLEY, KEITH R.;LEWIS, JENNY A.;FENWICK, G. ROGER, J. CHEM. SOC. PERKIN TRANS. PT 1,(1990) N, C. 2273-2276

  摘要：

  DOI：
• 作为产物：
  描述：

  potassium;[(E)-[2-(1H-indol-3-yl)-1-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]sulfanylethylidene]amino] sulfate 生成 Indolylglucosinolate
  参考文献：
  名称：

  VIAUD, M. C.;ROLLIN, P., TETRAHEDRON LETT., 31,(1990) N0, C. 1417-1418

  摘要：

  DOI：

文献信息

• P450 Monooxygenases of the cyp79 family
  申请人：——

  公开号：US20030166202A1

  公开（公告）日：2003-09-04

  The invention provides DNA coding for cytochrome P450 monooxygenases of the CYP79 family catalyzing the conversion of an aliphatic or aromatic amino acid or chain-elongated methionine homologue to the corresponding oxime. Preferred embodiments of the invention are enzymes catalyzing the conversion of L-Valine and L-Isoleucine such as the cassava enzymes CYP79D1 and CYP79D2, enzymes catalyzing the conversion of tyrosine such as the Triglochin maritima enzymes CYP79E1 and CYP79E2, enzymes catalyzing the conversion of tryptophan to the corresponding oxime indole-3-acetaldoxime such as the Arabidopsis thaliana enzyme CYP79A2 and the Brassica napus enzyme CYP79B5, and enzymes catalyzing the conversion of a chain-elongated methionine homologue such as the Arabidopsis thaliana enzymes CYP79F1 and CYP79F2. Transgenic expression of said DNA or parts thereof in plants can be used to manipulate the biosynthesis of corresponding glucosinolates or cyanogenic glucosides.

  该发明提供了编码CYP79家族细胞色素P450单加氧酶的DNA，其催化将脂肪族或芳香族氨基酸或链延长的蛋氨酸同源物转化为相应的肟类。该发明的优选实施例是催化L-缬氨酸和L-异亮氨酸转化的酶，例如木薯酶CYP79D1和CYP79D2，催化酪氨酸转化的Triglochin maritima酶CYP79E1和CYP79E2，催化色氨酸转化为相应的肟类吲哚-3-乙醛肟的Arabidopsis thaliana酶CYP79A2和Brassica napus酶CYP79B5，以及催化链延长的蛋氨酸同源物转化的Arabidopsis thaliana酶CYP79F1和CYP79F2。在植物中转基因表达该DNA或其部分可以用于操纵相应的硫代葡萄糖苷或氰基葡萄糖苷的生物合成。
• PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES
  申请人：Bednarek Pawel

  公开号：US20090028796A1

  公开（公告）日：2009-01-29

  The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention relates to the use of indole derivatives for the production of pesticides and the use of the compositions according to the invention as pesticides. The present invention is also directed to a process for producing a pesticidal composition and to pesticidal compositions prepared by this process. In addition, the invention relates to a process for preventing or combating pests and to a process for protecting plants against pests, especially against phytopathogenic fungi. Further, the invention is directed to plants or seeds as well as objects or materials which have been protected against pests by treatment with a composition according to the invention. Further, the invention is directed to a method for identifying a substance having pesticidal activity. Further, the invention is directed to a method of identifying the mode of action of and/or of providing binding proteins for a pesticidal compound of the present invention. Finally, the invention is directed to a method for diagnosing pest infection of a plant and to the use of a pesticidal compound of the present invention as diagnostic markers.

  本发明涉及包含吲哚衍生物的杀虫组合物。这些吲哚衍生物特别对植物病原真菌具有活性。此外，本发明涉及使用吲哚衍生物制备杀虫剂以及使用本发明中的组合物作为杀虫剂。本发明还涉及制备杀虫组合物的过程以及通过该过程制备的杀虫组合物。此外，本发明还涉及预防或对抗害虫的过程以及保护植物免受害虫，特别是植物病原真菌的过程。此外，本发明还涉及经过本发明中的组合物处理后受到保护的植物或种子以及物体或材料。本发明还涉及识别具有杀虫活性的物质的方法。此外，本发明还涉及识别本发明中杀虫化合物的作用方式和/或提供结合蛋白的方法。最后，本发明涉及诊断植物害虫感染的方法以及使用本发明中的杀虫化合物作为诊断标记的方法。
• [EN] GLYCEROL-BASED PRODUCT, PROCESS FOR OBTAINING SAME AND USE THEREOF IN THE MANUFACTURE OF DICHLOROPROPANOL<br/>[FR] PRODUIT À BASE DE GLYCÉROL, SON PROCÉDÉ D'OBTENTION ET SON UTILISATION DANS LA FABRICATION DE DICHLOROPROPANOL
  申请人：SOLVAY

  公开号：WO2009077528A1

  公开（公告）日：2009-06-25

  The invention relates to a glycerol-based product comprising at least one nitrogen-containing compound and of which the total content of nitrogen-containing compound expressed as elemental nitrogen (N) is less than or equal to 1 g of nitrogen (N)/kg of product, to a process for obtaining glycerol, and to its use in the manufacture of dichloropropanol and of derived products such as epichlorohydrin and products derived from epichlorohydrin.

  本发明涉及一种基于甘油的产品，其中至少含有一种含氮化合物，其含氮化合物的总含量以元素氮（N）表示，小于或等于每千克产品1克氮（N），以及甘油的制备方法和其在制造二氯丙醇及其衍生产品如环氧氯丙烷和由环氧氯丙烷衍生的产品中的应用。
• NMR imaging with Mn(II) coordination compositions
  申请人：SALUTAR, INC.

  公开号：EP0308983A2

  公开（公告）日：1989-03-29

  Enhanced T₁ and T₂ relaxation in NMRI is obtained with solutions of non-chelate coordination compounds of the formula: [Mn(II)(H₂O)mA1nA2oA3pA4q]+a(Y,Zr)-a In the formula, A1, A2, A3 and A4 are the same of different amino-substituted carboxylic acid groups having from 2 to 18 carbons; Y and Z are each the same or a different anion of a pharmaceutically acceptable inorganic acid or an organic carboxylic acid having from 2 to 18 carbons; a is valence of the ions; m, n, o, p, and q are each 1 or 0, (m + n + o + p + q) = 4, and (n + o + p + q) is preferably from 1 to 3; and r is 1, and if Y is a multivalent anion, r is 0 or 1. The solution has a pH within the range of from 4 to 9.5, preferably from 5 to 7, and optimally from 5 to 6.5, and for parenteral administration, a coordination compound concentration of from 0.5 to 4.0 wt%. Preferably, n is from 1 to 3, optimally from 2-4, and most optimally from 2 to 3, and Y and Z are monovalent. For example Y is preferably an anion of an aliphatic carboxylic acid having from 2 to 6 carbons such as acetic, propionic, n-butyric acid, isobutyric acid, valeric acid, isovaleric acid, pivalic acid or gluconic acid, and Z is an inorganic anion such as chloride or sulfate. A1, A2, A3 and A4 are preferably α-amino acids having from 2 to 6 carbons such as glycine.

  利用式中的非螯合物配位化合物溶液，可以增强 NMRI 中的 T₁ 和 T₂ 弛豫： [Mn(II)(H₂O)mA1nA2oA3pA4q]+a(Y,Zr)-a 式中 A1、A2、A3 和 A4 是具有 2 至 18 个碳原子的相同或不同的氨基取代的羧酸基团； Y 和 Z 分别是相同或不同的药学上可接受的无机酸阴离子或具有 2 至 18 个碳原子的有机羧酸阴离子； a 是离子的化合价； m、n、o、p 和 q 各为 1 或 0，（m + n + o + p + q）= 4，（n + o + p + q）最好为 1 至 3；以及 r 为 1，如果 Y 是多价阴离子，则 r 为 0 或 1。 溶液的 pH 值范围为 4 至 9.5，优选 5 至 7，最佳为 5 至 6.5，对于肠外给药，配位化合物的浓度为 0.5 至 4.0 wt%。n 最好为 1 至 3，最佳为 2 至 4，最理想为 2 至 3，Y 和 Z 为一价。例如，Y 最好是具有 2 至 6 个碳原子的脂肪族羧酸的阴离子，如乙酸、丙酸、正丁酸、异丁酸、戊酸、异戊酸、特戊酸或葡萄糖酸，Z 是无机阴离子，如氯化物或硫酸盐。A1、A2、A3 和 A4 最好是具有 2 至 6 个碳原子的 α-氨基酸，如甘氨酸。
• Cancer chemoprotective food products
  申请人：THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

  公开号：EP1219180A1

  公开（公告）日：2002-07-03

  Vegetable sources of cancer chemoprotective agents have been identified which are extraordinarily rich in glucosinolates, metabolic precursors or isothiocyanates. The vegetable sources are used to provide a dietary means of reducing the level of carcinogens in mammals.

  癌症化学保护剂的蔬菜来源已经确定，它们含有特别丰富的葡萄糖苷酸盐、代谢前体或异硫氰酸酯。这些蔬菜来源可作为降低哺乳动物体内致癌物质水平的膳食手段。