4-Nitro-3-hydrazino-pyridin-N-oxid | 13959-49-4

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 4-Nitro-3-hydrazino-pyridin-N-oxid
• 英文别名: 3-Hydrazino-4-nitro-pyridin-N-oxid；(4-Nitro-1-oxidopyridin-1-ium-3-yl)hydrazine
• CAS: 13959-49-4
• 化学式: C₅H₆N₄O₃
• 分子量: 170.128
• InChiKey: HOBKPPUKCRLLHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-Nitro-3-hydrazino-pyridin-N-oxid 在 一水合肼 作用下， 以 甲醇 为溶剂， 生成 5-Oxy-[1,2,3]triazolo[4,5-c]pyridin-1-ol; compound with hydrazine
  参考文献：
  名称：

  Comparison of the Effects of 5- and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4- and 7-Isomers^,

  摘要：

  [GRAPHICS]Synthesis of 5- and 6-HOAt has completed the full set of the four HOAt isomers derived from HOBt by insertion of a single nitrogen atom in the benzenoid nucleus. Comparison of the reactivity of all four isomers in model peptide coupling reactions has confirmed the unique character of the 7-isomer in promoting selectivity and maintaining configuration at the reactive carboxylic acid residue.

  DOI：

  10.1021/ol006013z
• 作为产物：
  描述：

  3-氟-4-硝基-N-氧化吡啶 在 一水合肼 作用下， 以 甲醇 为溶剂， 生成 4-Nitro-3-hydrazino-pyridin-N-oxid
  参考文献：
  名称：

  Comparison of the Effects of 5- and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4- and 7-Isomers^,

  摘要：

  [GRAPHICS]Synthesis of 5- and 6-HOAt has completed the full set of the four HOAt isomers derived from HOBt by insertion of a single nitrogen atom in the benzenoid nucleus. Comparison of the reactivity of all four isomers in model peptide coupling reactions has confirmed the unique character of the 7-isomer in promoting selectivity and maintaining configuration at the reactive carboxylic acid residue.

  DOI：

  10.1021/ol006013z

文献信息

• Comparison of the Effects of 5- and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4- and 7-Isomers^,
  作者：Louis A. Carpino、Hideko Imazumi、Bruce M. Foxman、Michael J. Vela、Peter Henklein、Ayman El-Faham、Jana Klose、Michael Bienert

  DOI：10.1021/ol006013z

  日期：2000.7.1

  [GRAPHICS]Synthesis of 5- and 6-HOAt has completed the full set of the four HOAt isomers derived from HOBt by insertion of a single nitrogen atom in the benzenoid nucleus. Comparison of the reactivity of all four isomers in model peptide coupling reactions has confirmed the unique character of the 7-isomer in promoting selectivity and maintaining configuration at the reactive carboxylic acid residue.