4-Methoxy-1H-indol-1-amine | 420786-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-Methoxy-1H-indol-1-amine
• 英文别名: 4-methoxyindol-1-amine
• CAS: 420786-83-0
• 化学式: C₉H₁₀N₂O
• 分子量: 162.191
• InChiKey: DEWBFPJNHNNBLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  40.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Methoxy-1H-indol-1-amine 、 2,6-二甲基苯甲醛 以 1,2-二氯乙烷 为溶剂， 以90%的产率得到(E)-1-(2,6-dimethylphenyl)-N-(4-methoxy-1H-indol-1-yl)methanimine
  参考文献：
  名称：

  使用 N-亚氨基导向基团对含丙烯酸酯的吲哚衍生物进行铑催化的区域选择性 C7 官能化

  摘要：

  开发了一种高效的铑催化吲哚 C7 位 C-H 烯化的方法。N-亚氨基导向基团被证明对金属催化剂的高区域选择性和反应性至关重要。通过从吲哚中合成吡喹酮的简洁四步合成进一步证明了该协议的实用性。

  DOI：

  10.1055/s-0036-1588530
• 作为产物：
  描述：

  4-甲氧基吲哚 、 氢氧化钾 、 hydroxylamine-O-sulfonic acid 在 氩 、 ice 、 甲苯 、 水 、 Brine 、 Sodium sulfate-III 、 silica 、 乙醚 、 正己烷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.2h， 以gave 1-amino-4-methoxyindole (0.79 g, 56%)的产率得到4-Methoxy-1H-indol-1-amine
  参考文献：
  名称：

  Benzoxazinone derivatives, their preparation and use

  摘要：

  本发明涉及公式（I）的新化合物或其药学上可接受的盐，其中Ar是苯基、萘基、单环杂芳基或双环杂芳基，所述Ar基可以选择性地被1-4个取代基取代，所述取代基可以是相同的或不同的，所述取代基选择自卤素、羟基、氰基、硝基、三氟甲基、三氟甲氧基、C1-6烷基、三氟甲烷基磺酰氧基、五氟乙基、C1-6烷氧基、芳基C1-6烷氧基、C1-6烷硫基、C1-6烷氧基C1-6烷基、C3-7环烷基C1-6烷氧基、C1-6酰基、C1-6烷氧羰基、C1-6烷基磺酰基、C1-6烷基亚砜基、C1-6烷基磺酰氧基、C1-6烷基磺酰基C1-6烷基、芳基磺酰基、芳基磺酰氧基、芳基磺酰基C1-6烷基、C1-6烷基磺酰胺基、C1-6烷基酰胺基、C1-6烷基磺酰胺基C1-6烷基、C1-6烷基酰胺基C1-6烷基、芳基磺酰胺基、芳基羧酰胺基、烷基磺酰胺基C1-6烷基、芳基羧酰胺基C1-6烷基、芳基羰基、芳基C1-6烷基、芳基C1-6烷酰基、一组R <3>OCO（CH2）s，R <3>CON（R <4>）（CH2）s，R <3>R <4>NCO（CH2）s或R <3>R <4>NSO2（CH2），其中R <3>和R <4>各自独立地表示氢原子或C1-4烷基，或R <3>和R <4>形成C3-6杂氮环烷或C3-6（2-氧代）杂氮环烷环的一部分，s表示0或1-4的整数，以及一组Ar <1> Z，其中Z表示单键，O，S或CH2，Ar <1>表示苯基或单环杂芳基，所述Ar <1>基可以选择性地被1-3个取代基取代，所述取代基可以是相同的或不同的，所述取代基选择自卤素、羟基、氰基、三氟甲基、C1-6烷基、C1-6烷氧基或C1-6烷酰基；当Ar是苯基或单环杂芳基时，相对位于取代基可以连接成5-或6-成员环；R <1>是氢、C1-6烷基、C3-6烯基、C3-6炔基或芳基C1-6烷基；R <2>是卤素、C1-6烷基、氰基、CF3、C1-6烷酰基、C1-6烷氧基或羟基；X是CH或N；Y是单键、O或C═O；p是0、1或2；r是0、1、2或3；m是2、3或4；n和q分别为1或2。还公开了制备这些化合物的方法，包含它们的药物组合物以及它们作为治疗各种中枢神经系统疾病，包括抑郁和/或焦虑的药物的用途。

  公开号：

  US06939871B2

文献信息

• BENZOXAZINONE DERIVATIVES, THEIR PREPARATION AND USE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1330460B1

  公开（公告）日：2007-03-21
• US6939871B2
  申请人：——

  公开号：US6939871B2

  公开（公告）日：2005-09-06
• [EN] BENZOXAZINONE DERIVATIVES, THEIR PREPARATION AND USE<br/>[FR] DERIVES DE BENZOXAZINONE, LEUR PREPARATION ET UTILISATION
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2002034754A2

  公开（公告）日：2002-05-02

  The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, naphthyl, a monocyclic heteroaromatic group or a bicyclic heteroaromatic group, said Ar group being optionally substituted by 1-4 substituents, which may be the same or different, and which are selected from the group consisting of: halogen, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6alkyl, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-6alkoxy, arylC1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-6alkyl, C3-7cycloalkylC1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyloxy, C1-6alkylsulfonylC1-6alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6alkyl, C1-6alkylsulfonamido, C1-6alkylamido, C1-6alkylsulfonamidoC1-6alkyl, C1-6alkylamidoC1-6alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamidoC1-6alkyl, arylcarboxamidoC1-6alkyl, aroyl, aroylC1-6alkyl, arylC1-6alkanoyl, a group R3OCO(CH¿2?)s, R?3CON(R4)(CH¿2)s, R3R4NCO(CH¿2?)s or R?3R4NSO¿2(CH2) where each of R?3 and R4¿ independently represents a hydrogen atom or C¿1-4?alkyl or R?3 and R4¿ form part of a C¿3-?6azacyloalkane or C3-6(2-oxo)azacycloalkane ring and s represents zero or an integer from 1 to 4, and a group Ar?1¿ Z, wherein Z represents a single bond, O, S or CH¿2? and Ar?1¿ represents a pheyl or a monocyclic heteroaromatic group, said Ar1 group being optionally substituted by 1-3 substituents, which may be the same or different, and which are selected from the group consisting of a halogen, hydroxy, cyano, trifluoromethyl, C¿1-6?alkyl, C1-6alkoxy or C1-6alkanoyl; when Ar is a phenyl or a monocyclic heteroaromatic group, substitutens positioned ortho to one another may be linked to form a 5- or 6-membered ring; R?1¿ is hydrogen, C¿1-6?alkyl, C3-6alkenyl, C3-6alkynyl or arylC1-6alkyl; R?2¿ is halogen, C¿1-6?alkyl, cyano, CF3, C1-6alkanoyl, C1-6alkoxy or hydroxy; X is CH or N; Y is a single bond, O, or C=O; p is 0, 1 or 2; r is 0, 1, 2 or 3; m is 2, 3 or 4; n and q are independently 1 or 2. Processes for preparing the compounds, pharmaceutical compositions containing them and their use as medicaments for various CNS disorders, including deression and/or anxiety, are also disclosed.
• Rhodium-Catalyzed Regioselective C7-Functionalization of Indole Derivatives with Acrylates by Using an N-Imino Directing Group
  作者：Lanting Xu、Lushi Tan、Dawei Ma

  DOI：10.1055/s-0036-1588530

  日期：2017.12

  An efficient rhodium-catalyzed method for C–H olefination at the C7 position of indoles has been developed. The N-imino directing group was shown to be crucial for high regioselectivity and reactivity of the metal catalyst. The utility of this protocol was further demonstrated through a concise, four-step synthesis of pyroquilon from indole.

  开发了一种高效的铑催化吲哚 C7 位 C-H 烯化的方法。N-亚氨基导向基团被证明对金属催化剂的高区域选择性和反应性至关重要。通过从吲哚中合成吡喹酮的简洁四步合成进一步证明了该协议的实用性。
• Benzoxazinone derivatives, their preparation and use
  申请人：——

  公开号：US20040063704A1

  公开（公告）日：2004-04-01

  The present invention relates to novel compounds of formula (1) or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, naphthyl, a monocyclic heteroaromatic group or a bicyclic heteroaromatic group, said Ar group being optionally substituted by 1-4 substituents, which may be the same or different, and which are selected from the group consisting of: halogen, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, C 1-6 alkyl, trifluoromethanesulfonyloxy, pentafluoroethyl, C 1-6 alkoxy, arylC 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkoxyC 1-6 -alkyl, C 3-7 cycloalkylC 1-6 alkoxy, C 1-6 alkanoyl, C 1-6 alkoxycarbonyl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyloxy, C 1-6 alkylsulfonylC 1-6 alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC 1-6 alkyl, C 1-6 alkylsulfonamido, C 1-6 alkylamido, C 1-6 alkylsulfonamidoC 1-6 alkyl, C 1-6 alkylamidoC 1-6 alkyl, arylsulfonamido, arylcarboxamido, arylsullonamidoC 1-6 alkyl, arylcarboxamidoC 1-6 alkyl, aroyl, arylC 1-6 alkyl, arylC 1-6 alkanoyl, a group R 3 OCO(CH 2 ) s , R 3 CON(R 4 )(CH 2 ) s , R 3 R 4 NCO(C 2 ) s or R 3 R 4 NSO 2 (CH 2 ) where each of R 3 and R 4 independently represents a hydrogen atom or C 1-4 alkyl or R 3 and R 4 form part of a C 1-6 azacyloalkane or C 3- 6 (2-oxo)azacycloalkane ring and s represents zero or an integer from 1 to 4, and a group Ar 1 Z, wherein Z represents a single bond, O, S or CH 2 and Ar 1 represents a phenyl or a monocyclic heteroaromatic group, said Ar 1 group being optionally substituted by 1-3 substituents, which may be the same or different, and which are selected from the group consisting of a halogen, hydroxy, cyano, trifluoromethyl, C 1-6 alkyl, C 1-6 alkoxy or C 1-6 alkanoyl; when Ar is a phenyl or a monocyclic heteroaromatic group, substitutents positioned ortho to one another may be linked to form a 5- or 6-membered ring: R 1 is hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl or arylC 1-6 alkyl; R 2 is halogen, C 1-6 alkyl, cyano, CF 3 , C 1-6 alkanoyl, C 1-6 alkoxy or hydroxy; X is CH or N; Y is a single bond, O, or C═O; p is 0, 1 or 2; r is 0, 1, 2 or 3; m is 2, 3 or 4; n and q are independently 1 or 2. Processes for preparing the compounds, pharmaceutical compositions containing them and their use as medicaments for various CNS disorders, including deression and/or anxiety, are also disclosed.

  本发明涉及公式（1）的新化合物或其药学上可接受的盐，其中Ar是苯基，萘基，单环杂芳基或双环杂芳基，所述Ar基可以选择性地被1-4个取代基取代，这些取代基可以相同或不同，选自以下群组：卤素，羟基，氰基，硝基，三氟甲基，三氟甲氧基，C1-6烷基，三氟甲磺酰氧基，五氟乙基，C1-6烷氧基，芳基C1-6烷氧基，C1-6烷硫基，C1-6烷氧基C1-6烷基，C3-7环烷基C1-6烷氧基，C1-6酰基，C1-6烷氧羰基，C1-6烷基磺酰基，C1-6烷基亚磺基，C1-6烷基磺酰氧基，C1-6烷基磺酰基C1-6烷基，芳基磺酰基，芳基磺酰氧基，芳基磺酰基C1-6烷基，C1-6烷基磺酰胺基，C1-6烷基酰胺基，C1-6烷基磺酰胺基C1-6烷基，C1-6烷基酰胺基C1-6烷基，芳基磺酰胺基，芳基羧酰胺，芳基磺酰胺基C1-6烷基，芳基羧酰胺基C1-6烷基，酰基，芳基C1-6烷基，芳基C1-6酰基，一个R3OCO（CH2）s，R3CON（R4）（CH2）s，R3R4NCO（C2）s或R3R4NSO2（CH2）组，其中R3和R4各自独立地表示氢原子或C1-4烷基，或R3和R4构成C1-6氮杂环烷或C3-6（2-氧代）氮杂环烷环，s表示零或1-4的整数，以及一个Ar1Z基，其中Z表示单键，O，S或CH2，Ar1表示苯基或单环杂芳基，所述Ar1基可以选择性地被1-3个取代基取代，这些取代基可以相同或不同，选自以下群组：卤素，羟基，氰基，三氟甲基，C1-6烷基，C1-6烷氧基或C1-6酰基；当Ar是苯基或单环杂芳基时，相对位于一个环上的取代基可以连接形成5-或6-成员环；R1是氢，C1-6烷基，C3-6烯基，C3-6炔基或芳基C1-6烷基；R2是卤素，C1-6烷基，氰基，CF3，C1-6酰基，C1-6烷氧基或羟基；X是CH或N；Y是单键，O或C═O；p是0，1或2；r是0，1，2或3；m是2，3或4；n和q独立地为1或2。还公开了制备这些化合物的方法，包含它们的制药组合物以及它们作为治疗各种中枢神经系统疾病，包括抑郁和/或焦虑的药物的用途。