4-(3-acetoxypropoxy)-3-methoxyacetophenone | 207298-40-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(3-acetoxypropoxy)-3-methoxyacetophenone
• 英文别名: 3-(4-Acetyl-2-methoxyphenoxy)propyl acetate
• CAS: 207298-40-6
• 化学式: C₁₄H₁₈O₅
• 分子量: 266.294
• InChiKey: KUMZHKQVOAASGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(3-acetoxypropoxy)-3-methoxyacetophenone 在 硝酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以3.8 g (81.5%)的产率得到4-(3-acetoxypropoxy)-3-methoxy-6-nitroacetophenone
  参考文献：
  名称：

  DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY

  摘要：

  提供了快速和高精度的基于质谱的过程，用于检测生物样本中的特定核酸序列。根据要检测的序列，这些过程可以用于诊断遗传疾病或染色体异常；疾病或状况的易感性，病原体感染，或用于确定身份或遗传。

  公开号：

  US20020042112A1

文献信息

• DNA Diagnostics Based on Mass Spectrometry
  申请人：Koster Hubert

  公开号：US20090023150A1

  公开（公告）日：2009-01-22

  Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

  提供了快速和高度准确的基于质谱的过程，用于检测生物样本中的特定核酸序列。根据要检测的序列，这些过程可以用于诊断遗传疾病或染色体异常；疾病或状况的易感性，病原体感染，或用于确定身份或遗传。
• DNA diagnostics based on mass spectrometry
  申请人：Koster Hubert

  公开号：US20070202514A1

  公开（公告）日：2007-08-30

  Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

  提供了快速且高度准确的基于质谱的过程，用于在生物样本中检测特定的核酸序列。根据要检测的序列，这些过程可以用于诊断遗传病或染色体异常；疾病或状况的易感性，病原体感染，或用于确定身份或遗传。
• Mass spectrometric detection of polypeptides
  申请人：SEQUENOM, INC.

  公开号：EP1296143A2

  公开（公告）日：2003-03-26

  A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity.

  本发明提供了一种利用质谱确定目标多肽身份的方法。根据待鉴定的目标多肽，所公开的过程可用于诊断遗传疾病或染色体异常、易患疾病或病症或感染病原体；或用于确定身份或遗传。
• high density immobilization of nucleic acids
  申请人：SEQUENOM, INC.

  公开号：EP1457496A1

  公开（公告）日：2004-09-15

  The invention provides a dispensing apparatus for dispensing nanovolumes of fluid in chemical or biological procedures onto the surface of a substrate, comprising: a housing having a plurality of sides and a bottom portion having formed therein a plurality of apertures, said sides and bottom portion of said housing defining an interior volume, one or more fluid transmitting vesicles, mounted within said apertures, having a nanovolume sized fluid holding chamber for holding nanovolumes of fluid, said fluid holding chamber being disposed in fluid communication with said interior volume of said housing, and dispensing means in communication with said interior volume of said housing for selectively dispensing nanovolumes of fluid from said nanovolume sized fluid transmitting vesicles when the fluid is loaded with said fluid holding chambers of said vesicles, whereby said dispensing means dispenses nanovolumes of the fluid onto the surface of the substrate when the apparatus is disposed over and in registration with the substrate.

  本发明提供了一种分配装置，用于在化学或生物程序中将纳米体积的流体分配到基底表面，该装置包括 具有多个侧面和底部的壳体，壳体的侧面和底部形成多个孔，壳体的侧面和底部限定了内部容积、 一个或多个流体传输囊泡，安装在所述孔内，具有纳米体积大小的流体容纳腔，用于容纳纳米体积的流体，所述流体容纳腔与所述外壳的内部容积流体相通，以及 与所述外壳的所述内部容积相通的分配装置，用于在流体装入所述囊泡的所述流体容纳室时，从所述纳米容积大小的流体传输囊泡中选择性地分配纳米容积的流体，从而当设备放置在基底上方并与基底相匹配时，所述分配装置将纳米容积的流体分配到基底的表面上。
• High density immobilization of nucleic acids
  申请人：SEQUENOM, INC.

  公开号：EP1460083A1

  公开（公告）日：2004-09-22

  The invention provides a method for analyzing a material, comprising: providing a vesicle suitable for carrying a fluid having said material therein, disposing said vesicle adjacent a first location of a surface of a substrate, controlling said vesicle to deliver a nanoliter volume of the fluid to provide a defined and controlled volume of said fluid at said first location of said surface of the substrate, moving said vesicle to a second position adjacent a second location on said surface of the substrate to dispense a defined and controlled volume of said material along an array of locations on said substrate surface, and performing mass spectrometry analysis for said material at each location of said array.

  本发明提供了一种分析材料的方法，包括 提供适用于携带含有所述材料的流体的囊泡、 将所述囊泡放置在基底表面的第一位置附近、 控制所述囊泡输送纳升体积的流体，以便在所述基底表面的第一位置提供确定和受控的流体体积、 将所述囊泡移动到与所述基底表面第二位置相邻的第二位置，以沿着所述基底表面的位置阵列分配确定和受控体积的所述材料，以及 在所述阵列的每个位置对所述材料进行质谱分析。