[4-(3-甲基-1,2,4-恶二唑-5-基)苯基]甲醇 | 362529-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: [4-(3-甲基-1,2,4-恶二唑-5-基)苯基]甲醇
• 英文名称: [4-(3-Methyl-1,2,4-oxadiazol-5-yl)phenyl]methanol
• CAS: 362529-02-0
• 化学式: C₁₀H₁₀N₂O₂
• mdl: MFCD09025867
• 分子量: 190.2
• InChiKey: OFHPDFFUEDRYNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  59.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors
  申请人：——

  公开号：US20020091104A1

  公开（公告）日：2002-07-11

  The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. 1 The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.

  本发明包括下式所代表的一类新型化合物，它们是 PTP-1B 酶的抑制剂。 1 本发明还包括治疗或预防 PTP-1B 介导的疾病（包括糖尿病）的药物组合物和方法。
• SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS
  申请人：Merck Frosst Canada & Co.

  公开号：EP1268494A1

  公开（公告）日：2003-01-02
• US6498151B2
  申请人：——

  公开号：US6498151B2

  公开（公告）日：2002-12-24
• [EN] SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS<br/>[FR] ACIDES ARYLDIFLUOROMETHYL PHOSPHONIQUES SUBSTITUES SOUFRE EN TANT QU'INHIBITEURS DE AS PTP-1B
  申请人：MERCK FROSST CANADA INC

  公开号：WO2001070753A1

  公开（公告）日：2001-09-27

  The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme . The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.