benzo[b]thiophene-4,5-dione | 875254-06-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: benzo[b]thiophene-4,5-dione
• 英文别名: 1-benzothiophene-4,5-dione
• CAS: 875254-06-1
• 化学式: C₈H₄O₂S
• 分子量: 164.185
• InChiKey: UZPARQXEDXDHLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzo[b]thiophene-4,5-dione 在 sodium sulfate 、 silver(l) oxide 作用下， 以 乙醚 、 苯 为溶剂， 反应 10.25h， 生成 ethyl 4,5-dioxo-3-propyl-4,5-dihydrobenzo[2,1-b:3,4-b']dithiophene-2-carboxylate
  参考文献：
  名称：

  Synthesis of Benzo[2,1-b:3,4-b’]dithiophene-4,5-dione Derivatives

  摘要：

  The 1-trimethylsilylimidazole-mediated thiophene ring formation from 6-acylbenzo[b]thiophene-4,5-diones (3), which. were prepared utilizing photoacylation of benzo[b]thiophene-4,5-dione (1) with aliphatic aldehydes, and ethyl mercaptoacetate, followed by acid hydrolysis and oxidation with cerium(IV) ammonium nitrate (CAN), led to one-pot formation of the 3-substituted ethyl 4,5dioxo-4,5-dihydrobenzo[2,1-b:3,4-b ']dithiophene-2-carboxylates (4) in satisfactory yields.

  DOI：

  10.3987/com-06-10779
• 作为产物：
  描述：

  4,5-二甲氧基-1-苯并噻吩 在 三溴化硼 、 silver(l) oxide 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 benzo[b]thiophene-4,5-dione
  参考文献：
  名称：

  Synthesis of Benzo[2,1-b:3,4-b’]dithiophene-4,5-dione Derivatives

  摘要：

  The 1-trimethylsilylimidazole-mediated thiophene ring formation from 6-acylbenzo[b]thiophene-4,5-diones (3), which. were prepared utilizing photoacylation of benzo[b]thiophene-4,5-dione (1) with aliphatic aldehydes, and ethyl mercaptoacetate, followed by acid hydrolysis and oxidation with cerium(IV) ammonium nitrate (CAN), led to one-pot formation of the 3-substituted ethyl 4,5dioxo-4,5-dihydrobenzo[2,1-b:3,4-b ']dithiophene-2-carboxylates (4) in satisfactory yields.

  DOI：

  10.3987/com-06-10779

文献信息

• [EN] BICYCLIC HETEROARYL COMPOUNDS AS GPR119 RECEPTOR AGONISTS<br/>[FR] COMPOSÉS HÉTÉROARYLES BICYCLIQUES EN TANT QU'AGONISTES DU RÉCEPTEUR GPR119
  申请人：CENTAURUS BIOPHARMA CO LTD

  公开号：WO2012103806A1

  公开（公告）日：2012-08-09

  The present invention provides a new class of bicyclic heteroaryl compounds represented by Formula (I), pharmaceutical compositions containing these compounds, and their use for modulating the activity of GPR119 in the treatment of metabolic disorders and complications thereof, as well as methods for the treatment of the metabolic disorders and complications thereof.

  本发明提供了一类新的双环杂环芳基化合物，其化学式表示为（I），包含这些化合物的药物组合物，以及它们在调节GPR119活性以治疗代谢紊乱及其并发症方面的用途，以及治疗代谢紊乱及其并发症的方法。
• BICYCLIC HETEROARYL COMPOUNDS AS GPR119 RECEPTOR AGONISTS
  申请人：Xiao Dengming

  公开号：US20140018380A1

  公开（公告）日：2014-01-16

  The present invention provides a new class of bicyclic heteroaryl compounds represented by Formula I, pharmaceutical compositions containing these compounds, and their use for modulating the activity of GPR119 in the treatment of metabolic disorders and complications thereof, as well as methods for the treatment of the metabolic disorders and complications thereof.

  本发明提供了一类新的双环杂环芳烃化合物，其化学式为I，以及含有这些化合物的药物组合物，以及它们在治疗代谢紊乱及其并发症中调节GPR119活性的用途，以及治疗代谢紊乱及其并发症的方法。
• METHODS OF MODULATING CELL PROLIFERATION AND CYST FORMATION IN POLYCYSTIC KIDNEY AND LIVER DISEASES
  申请人：MCW Research Foundation, Incorporated

  公开号：EP2061450A2

  公开（公告）日：2009-05-27
• US4133814A
  申请人：——

  公开号：US4133814A

  公开（公告）日：1979-01-09
• [EN] METHODS OF MODULATING CELL PROLIFERATION AND CYST FORMATION IN POLYCYSTIC KIDNEY AND LIVER DISEASES<br/>[FR] MÉTHODES DE MODULATION DE LA PROLIFÉRATION CELLULAIRE ET LA FORMATION DE KYSTES DANS LES MALADIES POLYKYSTIQUE DU REIN ET DU FOIE
  申请人：MCW RES FOUND INC

  公开号：WO2008034011A2

  公开（公告）日：2008-03-20

  [EN] The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20- HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD), ARPKD associated congenital hepatic fibrosis, ARPKD associated Caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to prevent or treat the disease.
  [FR] L'invention porte sur une méthode de prévention et traitement de l'affection autosomique dominante du rein polykystique(ADPKD), de l'affection autosomique récessive du rein polykystique(ARPKD), de la fibrose hépatique congénitale associée à l'ARPKD, de la maladie de Caroli associée à l'ARPKD, ou du cholangiocarcinome, consistant à administrer à un mammifère le nécessitant un inhibiteur de l'enzyme synthétisant le 20-HETE ou un antagoniste du 20-HETE, en quantité suffisante pour prévenir ou traiter la maladie.