[(3S,8S,9S,10R,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (9Z,12Z,15Z)-octadeca-9,12,15-trienoate | 2545-22-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(3S,8S,9S,10R,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• 英文别名: [(10R,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• CAS: 2545-22-4
• 化学式: C₄₅H₇₄O₂
• 分子量: 647.1
• InChiKey: FYMCIBHUFSIWCE-BGFOOHCMSA-N

物化性质

• 沸点：
  678.9±44.0 °C(Predicted)
• 密度：
  0.97±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）
• LogP：
  17.490 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  15.2
• 重原子数：
  47
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性的 Cholesteryl Linolenate 是一种内源性代谢产物。

文献信息

• Liquid crystal dispersed polymer electrooptical films having reverse morphology
  申请人：Sniaricerche S.C.P.A.

  公开号：EP0927753A1

  公开（公告）日：1999-07-07

  The invention provides a liquid crystal dispersed polymer electrooptical film comprising a liquid crystal material and a polymer material in which the electrooptical film has a reverse morphology and the liquid crystal material has cholesteric properties. The invention also provides a liquid crystal dispersed polymer electrooptical film comprising a liquid crystal material and a polymer material in which the electrooptical film has a reverse morphology and substantially no memory effect. Methods for making these electrooptical films are also provided.

  本发明提供了一种由液晶材料和聚合物材料组成的液晶分散聚合物光电膜，其中光电膜具有反向形态，液晶材料具有胆甾烯特性。本发明还提供了一种由液晶材料和聚合物材料组成的液晶分散聚合物光电薄膜，其中的光电薄膜具有反向形态，基本上没有记忆效应。本发明还提供了制作这些电光薄膜的方法。
• Use of high wavenumber Raman spectroscopy for measuring tissue
  申请人：River Diagnostics B.V.

  公开号：EP1821097A1

  公开（公告）日：2007-08-22

  The invention is related to the instrument for measuring a Raman signal of tissue, the instrument comprising a laser, a signal detection unit for measuring the Raman signal, and a fiber optic probe, wherein the fiber optic probe comprises one or more optical fibers for directing laser light onto the tissue and for collecting light that is scattered by the tissue and guiding the collected light away from the tissue towards the signal detection unit, wherein the fiber or fibers for collecting light have substantially no Raman signal in one or more parts of the 2500-3700 cm-1 spectral region, and wherein the detection unit records the Raman signal scattered by the tissue in said spectral region. The invention enables ex vivo, in vitro and in vivo analysis and diagnosis of atherosclerotic plaque and detection of tumor tissue with great advantages over current state-of-the-art technology.

  本发明涉及用于测量组织拉曼信号的仪器，该仪器包括一个激光器、一个用于测量拉曼信号的信号检测单元和一个光纤探头，其中光纤探头包括一个或多个光纤，用于将激光照射到组织上，并收集组织散射的光，将收集的光从组织引导到信号检测单元、其中，用于收集光的光纤在 2500-3700 cm-1 光谱区的一个或多个部分基本上没有拉曼信号，而检测单元记录组织在所述光谱区散射的拉曼信号。本发明可对动脉粥样硬化斑块进行体外、体内和体外分析和诊断，并检测肿瘤组织，与目前最先进的技术相比具有极大的优势。
• SOLUTION STABLE ENZYME COMPOSITION
  申请人：AB Enzymes Oy

  公开号：EP3722418A1

  公开（公告）日：2020-10-14

  A solution stable enzyme composition comprising an enzyme component, a stabilizer component, an optional antimicrobial preservative and water is disclosed, as well as its use in manufacturing of pulp and paper.

  公开了一种溶液稳定酶组合物，其中包括酶成分、稳定剂成分、可选的抗菌防腐剂和水，并公开了其在纸浆和纸张制造中的用途。
• Drug delivery means
  申请人：TheraSyn Sensors, Inc.

  公开号：US10092516B2

  公开（公告）日：2018-10-09

  The invention broadly comprises a chemical composition including a plurality of cholesteryl esters arranged to form a vesicle. In several embodiments, all of the plurality of cholesteryl esters have a same molecular length, which in some embodiments provides a vesicle having a generally smooth outer surface, while in other embodiments, a portion of the plurality of cholesteryl esters have different molecular lengths, which in some embodiments provides a vesicle having a generally irregular outer surface. In yet further embodiments, a shape of the vesicle is selected from the group consisting of spherical, oval, disc-like, tubular and polyhedral shapes, and in yet other embodiments, a wall of the vesicle is selected from the group consisting of a monolayer and a bilayer. In still further embodiments, the chemical composition further includes a polyethylene glycol coat of mixed polymer size. In some embodiments, the plurality of cholesteryl esters include at least two different cholesteryl esters, and in some of these embodiments, the at least two different cholesteryl esters are selected from the group consisting of: cholesteryl myristate, cholesteryl laurate, cholesteryl dodeconate, cholesteryl palmitate, cholesteryl arachidonate, cholesteryl behenate, cholesteryl linoleate, cholesteryl linolenate, cholesteryl oleate and cholesteryl stearate.

  本发明大致包括一种化学组合物，其中包括排列成囊泡的多个胆固醇酯。在一些实施方案中，所有的胆固醇酯具有相同的分子长度，这在某些实施方案中提供了具有大致光滑外表面的囊泡，而在其他实施方案中，部分胆固醇酯具有不同的分子长度，这在某些实施方案中提供了具有大致不规则外表面的囊泡。在更进一步的实施方案中，囊泡的形状选自球形、椭圆形、圆盘形、管状和多面体形组成的组，而在另一些实施方案中，囊泡的壁选自单层和双层组成的组。在更进一步的实施方案中，化学组合物进一步包括混合聚合物尺寸的聚乙二醇外套。在一些实施方案中，多个胆固醇酯包括至少两种不同的胆固醇酯，在其中一些实施方案中，至少两种不同的胆固醇酯选自由以下组成的组：胆甾烯基肉豆蔻酸酯、胆甾烯基月桂酸酯、胆甾烯基十二酸酯、胆甾烯基棕榈酸酯、胆甾烯基花生四烯酸酯、胆甾烯基山嵛酸酯、胆甾烯基亚油酸酯、胆甾烯基亚麻酸酯、胆甾烯基油酸酯和胆甾烯基硬脂酸酯。
• Cholestosome vesicles for incorporation of molecules into chylomicrons
  申请人：TheraSyn Sensors, Inc.

  公开号：US10369114B2

  公开（公告）日：2019-08-06

  The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (“cholestosome”) consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.

  本发明涉及一种装载货物的胆固醇酯纳米粒子，该粒子具有中空隔室（"胆固醇体"），主要由至少一种非离子胆固醇酯和一种或多种封装的活性分子组成，在没有将所述分子装载到所述胆固醇体中的情况下，活性分子不能明显地通过肠细胞膜、胆甾体具有中性表面，能够像口服吸收的营养脂质一样通过细胞通路进入肠细胞，到达高尔基体。根据本发明，本发明的新型载货胆甾体能够将活性分子沉积在患者或受试者的细胞内，并对患者或受试者进行治疗或诊断。