Isostearyl ferulate | 675584-24-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Isostearyl ferulate
• 英文别名: 16-methylheptadecyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
• CAS: 675584-24-4
• 化学式: C₂₈H₄₆O₄
• 分子量: 446.7
• InChiKey: MWSZIMKFELTDLK-XUTLUUPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  32
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• UV ABSORBER FORMULATIONS
  申请人：Acker Stephanie

  公开号：US20100111884A1

  公开（公告）日：2010-05-06

  Disclosed is a UV filter composition comprising (a) an organic UV absorber of formula (1), wherein R 1 and R 2 , independently of one another, are C 3 -C 18 alkyl; C 2 -C 18 alkenyl; a radical of the formula —CH 2 —CH(OH)—CH 2 —O-T 1 ; or R 1 and R 2 are a radical of the formula (4a); R 7 is a direct bond; a straight-chain or branched C 1 -C 4 alkylene radical or a radical of the formula (I) or (II); R 8 , R 9 and R 10 , independently of one another, are C 1 -C 18 alkyl; C 1 -C 18 alkoxy or a radical of the formula (III); R 11 is C 1 -C 5 alkyl; m 1 is a number from 1 to 4; p 1 is 0; or a number from 1 to 5; A 1 is a radical of the formula (1b), (1c) or (1d); R 3 is hydrogen; C 1 -C 10 alkyl; —(CH 2 CHR 5 —O)n 1 -T 2 ; or —CH 2 —CH(—OH)—CH 2 —O-T 2 ; R 4 is hydrogen; M; C 1 -C 5 alkyl; or —(CH 2 )m 2 —O-T 3 ; R 5 is hydrogen; or methyl; T 1 , T 2 and T 3 independently from each other are hydrogen; or C 1 -C 18 alkyl; Q 1 is C 1 -C 18 alkyl, M is a metal cation; m 2 is 1 to 4; and n 1 is 1-16, (b) dimethyl capramide, (c) a cosmetically acceptable carrier; and water.

  本发明公开了一种紫外线过滤组合物，包括（a）式（1）的有机紫外线吸收剂，其中R1和R2独立地是C3-C18烷基；C2-C18烯基；式—CH2—CH（OH）— —O-T1的基团；或者R1和R2是式（4a）的基团；R7是直链或支链C1-C4烷基、式（I）或（II）的基团；R8、R9和R10独立地是C1-C18烷基、C1-C18烷氧基或式（III）的基团；R11是C1-C5烷基；m1是1至4的数字；p1是0或1至5的数字；A1是式（1b）、（1c）或（1d）的基团；R3是氢、C1-C10烷基、式—（ CHR5—O）n1-T2或式— —CH（—OH）— —O-T2；R4是氢、M、C1-C5烷基或式—（ ）m2—O-T3；R5是氢或甲基；T1、T2和T3互相独立地是氢或C1-C18烷基；Q1是C1-C18烷基，M是金属阳离子；m2是1至4的数字；n1是1-16，（b）二甲基辛酰胺，（c）化妆品可接受载体；和水。
• EXTERNAL PREPARATION FOR PERCUTANEOUS ADMINISTRATION CONTAINING NONSTEROIDAL ANTI-INFLAMMATORY ANALGESIC
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1661583A1

  公开（公告）日：2006-05-31

  An external preparation for percutaneous administration which contains a light-sensitive nonsteroidal anti-inflammatory analgesic and a UVA-shielding agent which inhibits the analgesic to cause light toxicity and a light allergy. This external preparation for percutaneous administration, which contains a nonsteroidal anti-inflammatory analgesic, can be prevented, with higher certainty, from causing the hypersensitivity to light attributable to light toxicity and a light allergy.

  一种用于经皮给药的外用制剂，它含有一种对光敏感的非甾体抗炎镇痛剂和一种 UVA 屏蔽剂，后者可抑制镇痛剂引起光毒性和光过敏。这种经皮给药的外用制剂含有一种非甾体类消炎镇痛药，可以更有把握地防止引起光毒性和光过敏的光过敏反应。
• ANTI-INFLAMMATORY ANALGESIC EXTERNAL PREPARATION
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1698330A1

  公开（公告）日：2006-09-06

  An adhesive patch comprising a substrate and a pressure-sensitive adhesive base, wherein the pressure-sensitive adhesive base comprises a rubbery polymer having double bonds in the main chain and a nonsteroidal anti-inflammatory analgesic and contains a UVA screening agent and/or UVB screening agent as a stabilizer for the rubbery polymer. The adhesive patch is excellent in the stability of the pressure-sensitive adhesive base and in drug infiltration into the skin.

  一种胶贴，包括基底和压敏胶基，其中压敏胶基包括主链中具有双键的橡胶聚合物和非甾体消炎镇痛剂，并含有作为橡胶聚合物稳定剂的 UVA 屏蔽剂和/或 UVB 屏蔽剂。这种贴片在压敏胶基的稳定性和药物渗入皮肤方面都非常出色。
• TRANSDERMAL PREPARATION FOR EXTERNAL USE CONTAINING NONSTEROIDAL ANTIINFLAMMATORY/ANALGESIC AGENT
  申请人：Hisamitsu Pharmaceutical Co., Inc.

  公开号：EP1872796A1

  公开（公告）日：2008-01-02

  A transdermal preparation for external use which contains a photosensitive NSAID and a UV blocker having a high ability to migrate into the skin. Thus, it becomes possible to ensure, in a transdermal preparation for external use containing a NSAID, the inhibition of the onset of light-induced non-immunological or immunological skin symptoms by the above-described component.

  一种外用透皮制剂，它含有一种光敏非甾体抗炎药和一种紫外线阻断剂，后者具有很强的皮肤迁移能力。因此，在含有非甾体抗炎药的透皮外用制剂中，上述成分可以确保抑制光引起的非免疫性或免疫性皮肤症状的发生。
• OIL DISPERSION OF POWDER BEING SURFACE-TREATED WITH SPECIFIC ACIDIC ESTER OIL, AND COSMETIC COMPOSITION CONTAINING THE SAME
  申请人：Miyoshi Kasei, Inc.

  公开号：EP1881039A1

  公开（公告）日：2008-01-23

  Provided are a dispersion excellent in the dispersibility of powder particles, dispersion stability, storage stability, and versatility; and a cosmetic blended with such dispersion. An oil dispersion of a surface-treated powder, comprising a surface-treated powder coated with a half ester oil, and a lipophilic solvent as a dispersion medium, wherein the half ester oil comprises an ester compound having 16 or more carbon atoms in total as can be obtained by reacting at least one kind of alcohols having 1 to 36 carbon atoms with at least one kind of carboxylic acids having 1 to 36 carbon atoms, and wherein the half ester oil has an acid value of 15 or more.

  本发明提供了一种在粉末颗粒分散性、分散稳定性、储存稳定性和多功能性方面都非常出色的分散体，以及一种用这种分散体调配的化妆品。 一种表面处理过的粉末的油分散液，包括涂有半酯油的表面处理过的粉末，以及作为分散介质的亲脂性溶剂，其中半酯油包括至少一种具有 1 至 36 个碳原子的醇和至少一种具有 1 至 36 个碳原子的羧酸反应得到的总共具有 16 个或更多碳原子的酯化合物，并且半酯油的酸值为 15 或更高。