[2-[(5-Fluoro-2-benzofuranyl)methyl]-1-piperidinyl]-4-quinolinylmethanone | 483279-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [2-[(5-Fluoro-2-benzofuranyl)methyl]-1-piperidinyl]-4-quinolinylmethanone
• 英文别名: [2-[(5-fluoro-1-benzofuran-2-yl)methyl]piperidin-1-yl]-quinolin-4-ylmethanone
• CAS: 483279-95-4
• 化学式: C₂₄H₂₁FN₂O₂
• 分子量: 388.4
• InChiKey: GNVQXWWRNNBUIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：BRANCH Clive Leslie

  公开号：US20090036442A1

  公开（公告）日：2009-02-05

  Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

  本发明涉及具有以下公式的N-芳酰基环状胺衍生物：其中变量如此处所定义，并且它们作为药物的使用，具体作为促进睡眠的药物，特别是促进睡眠的药物。
• N-aroyl cyclic amine derivatives as orexin receptor antagonists
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1705179A1

  公开（公告）日：2006-09-27

  This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.

  本发明涉及 N-芳酰基环胺衍生物及其作为药物的用途，特别是作为奥曲肽受体拮抗剂的用途。
• [EN] N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] DERIVES D'AMINE CYCLIQUES N-AROYLE UTILISES COMME ANTAGONISTES DU RECEPTEUR DE L'OREXINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2003002561A1

  公开（公告）日：2003-01-09

  This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen , NR3 or a group (CH¿2?), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar?2¿ represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.