3-(chloromethyl)-6-methoxy-pyridazine | 41227-73-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(chloromethyl)-6-methoxy-pyridazine
• 英文别名: 3-(Chloromethyl)-6-methoxypyridazine
• CAS: 41227-73-0
• 化学式: C₆H₇ClN₂O
• mdl: MFCD10698628
• 分子量: 158.587
• InChiKey: JFXSVKPIIFBWPF-UHFFFAOYSA-N

物化性质

• 沸点：
  325.3±27.0 °C(Predicted)
• 密度：
  1.243±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-isobutyl-2-(piperazin-1-yl)benzonitrile hydrochloride 、 3-(chloromethyl)-6-methoxy-pyridazine 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以73 %的产率得到4-isobutyl-2-(4-((6-methoxypyridazin-3-yl)methyl)piperazin-1-yl)benzonitrile
  参考文献：
  名称：

  [EN] COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING
  [FR] COMPOSÉS POUR LE TRAITEMENT DE LA DOULEUR, EN PARTICULIER DE LA DOULEUR NEUROPATHIQUE, ET/OU D'AUTRES MALADIES OU TROUBLES ASSOCIÉS À AT2R ET/OU À LA SIGNALISATION MÉDIÉE PAR AT2R

  摘要：

  The present invention relates to compounds that can be used for the prevention, treatment and/or management of pain, in particular chronic pain, such as neuropathic pain, and/or other diseases or disorders that are associated with AT2R and/or AT2R-mediated signaling.

  公开号：

  WO2023006893A1

文献信息

• (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
  申请人：LES LABORATOIRES SERVIER

  公开号：US10654849B2

  公开（公告）日：2020-05-19

  Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.

  式(I)化合物： 其中 R1、R2、J、K、L、n 和 W 如说明中所定义。 含有相同成分的医药产品，可用于治疗需要促凋亡剂和/或抗增生剂的病症。
• NEW (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Les Laboratoires Servier

  公开号：EP3468971A1

  公开（公告）日：2019-04-17
• (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：LES LABORATOIRES SERVIER

  公开号：US20190144449A1

  公开（公告）日：2019-05-16

  Compounds of formula (I): wherein R 1 , R 2 , J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
• [EN] COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE LA DOULEUR, EN PARTICULIER DE LA DOULEUR NEUROPATHIQUE, ET/OU D'AUTRES MALADIES OU TROUBLES ASSOCIÉS À AT2R ET/OU À LA SIGNALISATION MÉDIÉE PAR AT2R
  申请人：[en]CONFO THERAPEUTICS N.V.

  公开号：WO2023006893A1

  公开（公告）日：2023-02-02

  The present invention relates to compounds that can be used for the prevention, treatment and/or management of pain, in particular chronic pain, such as neuropathic pain, and/or other diseases or disorders that are associated with AT2R and/or AT2R-mediated signaling.