Quinacrine methanesulfonate | 316-05-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Quinacrine methanesulfonate
• 英文别名: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;methanesulfonic acid
• CAS: 316-05-2
• 化学式: C25H38ClN3O7S2
• 分子量: 592.2
• InChiKey: BSSDNUXUOKRRHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.98
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  163
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• [EN] COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS, USES AND METHOD OF MANAGEMENT OF MYELOPROLIFERATIVE DISORDER<br/>[FR] COMPOSITIONS, PROCÉDÉ DE PRÉPARATION DESDITES COMPOSITIONS, UTILISATIONS ET PROCÉDÉ DE GESTION DE TROUBLE MYÉLOPROLIFÉRATIF
  申请人：CELLWORKS GROUP INC

  公开号：WO2015068142A2

  公开（公告）日：2015-05-14

  The present disclosure relates to a pharmaceutical composition and a method to manage Myeloproliferative disorder or any associated condition, particularly, JAK2 (Janus Kinase 2) dominant (including JAK2V617F mutant) Myeloproliferative Disorder (MPD) and associated conditions. The disclosure provides composition comprising at least two components selected from a group comprising Phosphodiesterase Type 4 (PDE4) inhibitor, Autophagy inhibitor and AMPK agonist. The disclosure further relates to a process of preparing the said composition and a method of managing JAK2 dominant (including JAK2 V617F mutant) Myeloproliferative Disorder; existing alone or along with any other mutation.