5-chloro-1,3-oxazolo<4,5-h>quinoline-2-carboxylic acid sodium salt | 88362-77-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-chloro-1,3-oxazolo<4,5-h>quinoline-2-carboxylic acid sodium salt
• 英文别名: 5-chloro-1,3-oxazolo-[4,5-h]quinoline-2-carboxylate sodium salt；Sodium;5-chloro-[1,3]oxazolo[4,5-h]quinoline-2-carboxylate
• CAS: 88362-77-0
• 化学式: C₁₁H₄ClN₂O₃*Na
• 分子量: 270.607
• InChiKey: DEWQSIGHENRQCJ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-Chloro-[1,3]oxazolo[4,5-h]quinoline-2-carboxylic acid 生成 5-chloro-1,3-oxazolo<4,5-h>quinoline-2-carboxylic acid sodium salt
  参考文献：
  名称：

  MUSSER, J. H.;BROWN, R. E.

  摘要：

  DOI：

文献信息

• 2-Oxo-1,3-oxazolo[4,5-h] quinolines useful as anti-allergy agents
  申请人：USV Pharmaceutical Corp.

  公开号：US04563463A1

  公开（公告）日：1986-01-07

  New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formulae: ##STR1## and salts thereof, wherein R is hydrogen, acyl, carboethoxy,(3-methoxyphen)acetyl,(2-phenyl)propionyl, dimethylcarbamoyl or methyl, R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxy, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, and m is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.

  新的喹啉化合物，以及相应的1,2-；1,3-；和1,4-苯二氮杂环化合物，其中喹啉化合物的化学式为：##STR1##及其盐，其中R为氢，酰基，羧乙氧基，(3-甲氧基苯)乙酰基，(2-苯基)丙酰基，二甲基氨基甲酰基或甲基，R.sub.1和R.sub.2分别为氢，低碳基，卤素，三氟甲基，氨基，低碳基氨基，低酰胺基，氰基，芳基，芳基/低碳基烯基，硝基，低炔基，低烯基，低碳基亚砜基，低碳基磺酰基，低碳氧羰基，羧基，低碳氧基，低碳酰基或低碳烯酰基，Y为氧，硫，氮或R.sub.3 N，其中R.sub.3为氢，低碳基，烯基，炔基，芳基，芳基烷基，酰基，氨基烷基或羧基烷基，Z为氧，硫或氮，X为氰基，羧酰氧基，羧基，甲氧基亚硝基，四唑基，羧酰氧基烷基或羧基烷基，m为0或1，可用作药物，特别是用于治疗哮喘，和/或作为制备用于治疗哮喘的化合物的中间体。
• Method of prevention and treatment of peptic ulcers
  申请人：Rorer Pharmaceutical Corporation

  公开号：US04831040A1

  公开（公告）日：1989-05-16

  Disclosed is a method for prophylactic and therapeutic treatment of peptic ulcers which comprises the administration of a pharmaceutical composition containing a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereon, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminolakyl, or carboxyalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxyl, carboxyl, formuloximino, tetrazolyl, carbalkoxyalky or caboxyalkyl, and m is 0 or 1, in admixture or in association with a pharmaceutically acceptable carrier.

  揭示了一种用于预防和治疗消化性溃疡的方法，包括给予含有化合物的药物组合物，该化合物的结构式为##STR1##或其药用可接受的盐，其中R.sub.1和R.sub.2独立地为氢、低碳烷基、卤素、三氟甲基、氨基、低碳烷基氨基、低酰胺基、氰基、芳基、芳基/低碳烷基、硝基、低炔基、低烯基、低碳烷基砜基、低碳烷基砜基、低碳氧基羰基、羧基、低碳氧基、低碳酰基或低烯酰基，Y为氧、硫、氮或R.sub.3 N，其中R.sub.3为氢、低碳烷基、烯基、炔基、芳基、芳基烷基、酰基、氨基烷基或羧基烷基，Z为氧、硫或氮，X为氰基、羧酰氧烷氧基、羧基、甲酰氧基、四唑基、羧酰氧烷基或羧酰氧基，m为0或1，与药用可接受的载体混合或与之结合。
• Certain 1,3-oxazolo[4,5H]quinolines useful as anti-allergy agents
  申请人：USV Pharmaceutical Corporation

  公开号：US04522947A1

  公开（公告）日：1985-06-11

  New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, and m is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.

  新的喹啉化合物，以及相应的1,2-；1,3-；和1,4-苯并二氮杂环化合物，其中喹啉化合物的化学式为：##STR1##及其盐，其中R.sub.1和R.sub.2独立地是氢、较低烷基、卤素、三氟甲基、氨基、较低烷基氨基、较低酰胺基、氰基、芳基、芳基/较低烷基、硝基、较低炔基、较低烯基、较低烷基亚砜基、较低烷基磺酰基、较低烷氧羰基、羧基、较低烷氧基、较低脂酰基或较低烯酰基，Y为氧、硫、氮或R.sub.3 N，其中R.sub.3为氢、较低烷基、烯基、炔基、芳基、芳基烷基、酰基、氨基烷基或羧基烷基，Z为氧、硫或氮，X为氰基、羰基烷氧基、羧基、甲氧基亚胺基、四唑基、羰基烷氧基烷基或羧基烷基，m为0或1，可用作药物，特别是用于治疗哮喘，和/或用作制备用于治疗哮喘的化合物的中间体。
• MUSSER, J. H.;BROWN, R. E.
  作者：MUSSER, J. H.、BROWN, R. E.

  DOI：——

  日期：——
• MUSSER, JOHN H.;BROWN, RICHARD E.
  作者：MUSSER, JOHN H.、BROWN, RICHARD E.

  DOI：——

  日期：——