4-((4-(2-aminoethoxy)phenyl)(cyclohexylidene)methyl)phenol | 918803-14-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-((4-(2-aminoethoxy)phenyl)(cyclohexylidene)methyl)phenol
• 英文别名: (4-hydroxyphenyl-4'-aminoethoxyphenyl)methylenecyclohexane；4-[[4-(2-aminoethoxy)phenyl]-cyclohexylidenemethyl]phenol
• CAS: 918803-14-2
• 化学式: C₂₁H₂₅NO₂
• 分子量: 323.435
• InChiKey: BAXLOXCPKVICBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-((4-(2-aminoethoxy)phenyl)(cyclohexylidene)methyl)phenol 在 盐酸 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 生成
  参考文献：
  名称：

  激素-PAMAM树状大分子共轭物：聚合物动力学和系链结构影响配体对受体的访问。

  摘要：

  DOI：

  10.1002/anie.200601923
• 作为产物：
  描述：

  4,4’-环己基亚甲基二苯酚 、 2-({[(2-甲基-2-丙基)氧基]羰基}氨基)乙基甲烷磺酸酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以50%的产率得到4-((4-(2-aminoethoxy)phenyl)(cyclohexylidene)methyl)phenol
  参考文献：
  名称：

  Nonclassical SNAPFL Analogue as a Cy5 Resonance Energy Transfer Partner

  摘要：

  We have synthesized a new SNAPFL analogue (1) that exhibits a large Stokes shift (78 nm) (abs. 542 nm, em. 620 nm) and a good quantum yield. Because of the large overlap between the emission spectrum of 1 and the absorption spectrum of Cy5, 1 functions well as a fluorescence donor to Cy5 and has been used in FRET-based experiments using estrogen receptor site-specifically labeled with Cy5 and a receptor ligand conjugated to SNAPFL.

  DOI：

  10.1021/ol801907b

文献信息

• A Blue-Absorbing Photolabile Protecting Group for <i>in Vivo</i> Chromatically Orthogonal Photoactivation
  作者：Ludovic Fournier、Carole Gauron、Lijun Xu、Isabelle Aujard、Thomas Le Saux、Nathalie Gagey-Eilstein、Sylvie Maurin、Sylvie Dubruille、Jean-Bernard Baudin、David Bensimon、Michel Volovitch、Sophie Vriz、Ludovic Jullien

  DOI：10.1021/cb400178m

  日期：2013.7.19

  The small and synthetically easily accessible 7-diethylamino4-thiocoumarinylmethyl photolabile protecting group has been validated for uncaging with blue light. It exhibits a significant action cross-section for uncaging in the 470-500 nm wavelength range and a low light absorption between 350 and 400 nm. These attractive features have been implemented in living zebrafish embryos to perform chromatic orthogonal photoactivation of two biologically active species controlling biological development with UV and blue-cyan light sources, respectively.
• Nonclassical SNAPFL Analogue as a Cy5 Resonance Energy Transfer Partner
  作者：Sung Hoon Kim、Jillian R. Gunther、John A. Katzenellenbogen

  DOI：10.1021/ol801907b

  日期：2008.11.6

  We have synthesized a new SNAPFL analogue (1) that exhibits a large Stokes shift (78 nm) (abs. 542 nm, em. 620 nm) and a good quantum yield. Because of the large overlap between the emission spectrum of 1 and the absorption spectrum of Cy5, 1 functions well as a fluorescence donor to Cy5 and has been used in FRET-based experiments using estrogen receptor site-specifically labeled with Cy5 and a receptor ligand conjugated to SNAPFL.
• Hormone–PAMAM Dendrimer Conjugates: Polymer Dynamics and Tether Structure Affect Ligand Access to Receptors
  作者：Sung Hoon Kim、John A. Katzenellenbogen

  DOI：10.1002/anie.200601923

  日期：2006.11.6