a-D-葡萄糖庚糖 | 6946-18-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: a-D-葡萄糖庚糖
• 英文名称: 6-(1,2-Dihydroxyethyl)oxane-2,3,4,5-tetrol
• CAS: 6946-18-5；1961-73-5；6946-17-4
• 化学式: C₇H₁₄O₇
• mdl: MFCD24390318
• 分子量: 210.18
• InChiKey: BGWQRWREUZVRGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  131
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• [EN] DETECTION OF MYCOBACTERIA<br/>[FR] DÉTECTION DE MYCOBACTÉRIES
  申请人：ISIS INNOVATION

  公开号：WO2011030160A1

  公开（公告）日：2011-03-17

  A method for determining the presence of mycobacteria species in an organism or biological sample, the method comprising adding to the organism or biological sample a probe molecule comprising a substrate and a label, which probe molecule can be incorporated into mycobacteria, the presence of mycobacteria being determined by a detector responsive to the presence of the label, optionally after applying a stimulus; suitable probe molecules include compounds comprising a label and a substrate, which label is can be detected by a detector responsive to the presence of the label, optionally after applying a stimulus, characterised by compound being able to engage with the active site of Antigen 85B (Ag85B) such that it can form simultaneous hydrogen bonds with two or more amino acids in the active site selected from Arg 43, Trp 264, Ser126, His 262 and Leu 42, or the corresponding amino acids in Antigen 85A (Ag85A) or Antigen 85C (Ag85C), at least one of which is with Ser126.

  一种用于确定生物体或生物样本中结核分枝杆菌种类存在的方法，该方法包括向生物体或生物样本中添加一种探针分子，该探针分子包括底物和标记，该探针分子可以被结核分枝杆菌所吸收，通过对标记的存在做出反应的探测器确定结核分枝杆菌的存在，可选地，在施加刺激后进行；适用的探针分子包括包含标记和底物的化合物，该标记可以被对标记的存在做出反应的探测器检测到，可选地，在施加刺激后进行，其特征在于该化合物能够与抗原85B（Ag85B）的活性位点结合，从而能够与所选活性位点中的两个或更多氨基酸同时形成氢键，所选活性位点包括Arg 43、Trp 264、Ser126、His 262和Leu 42，或者抗原85A（Ag85A）或抗原85C（Ag85C）中对应的氨基酸，其中至少一个与Ser126形成氢键。
• Bicyclo-octane and bicyclo-nonane derivatives, processes for their preparation and their use as herbicides
  申请人：HER MAJESTY THE QUEEN IN RIGHT OF NEW ZEALAND, DEPARTMENT OF SCIENTIFIC AND INDUSTRIAL RESEARCH, CHEMISTRY DIVISON

  公开号：EP0302599A2

  公开（公告）日：1989-02-08

  Bicyclo-octane and bicyclo-nonane derivatives are described having herbicidal and plant growth regulating properties. The derivatives are based on the general formula

  双环辛烷和双环壬烷衍生物具有除草和植物生长调节性能。这些衍生物基于一般公式。
• [EN] PHOSPHORYLATED HEPTOSE COMPOUNDS : PROCESS FOR THEIR PREPARATION AND USE<br/>[FR] COMPOSÉS HEPTOSE PHOSPHORYLÉS : LEUR PROCÉDÉ DE PRÉPARATION ET D'UTILISATION
  申请人：NAT RES COUNCIL CANADA

  公开号：WO2018205009A1

  公开（公告）日：2018-11-15

  Processes for the preparation of phosphorylated heptose compounds are provided. Embodiments of the invention relate to the chemical synthesis of heptopyranose phosphate compounds. Also, embodiments of the invention relate to the use of compounds according to the invention in modulating an immune response in a subject.

  提供了制备磷酸化庚糖化合物的过程。该发明实施例涉及庚糖吡喃糖磷酸化合物的化学合成。此外，该发明实施例涉及根据该发明在调节受试者的免疫反应中使用化合物。
• [EN] GALLOTANNINS AND ELLAGITANNINS AS REGULATORS OF CYTOKINE RELEASE<br/>[FR] GALLOTANIN ET ELLAGITANIN EN TANT QUE REGULATEURS DE LA LIBERATION DE CYTOKINES
  申请人：PENN STATE RES FOUND

  公开号：WO2001036436A1

  公开（公告）日：2001-05-25

  A means and method for increasing or inhibiting the secretion of cytokines using gallotannins and ellagitannins is described. The preferred cytokine release inhibiting compounds are dimeric gallotannins having a linker molecule that misaligns the carbohydrate cores of the compounds. The preferred cytokine release promoting gallotannins and ellagitannins include a diaryl ether linker unit. In comparison to the more structurally complex ellagitannins, the compounds of this invention are structurally simpler, easier to synthesize, and more potent.

  本发明涉及使用没食子酸和榄香酸类物质增加或抑制细胞因子的分泌的方法和手段。首选的抑制细胞因子释放的化合物是二聚没食子酸，其具有使化合物的碳水化合物核心错位的连接分子。首选的促进细胞因子释放的没食子酸和榄香酸类包括一个二芳基醚连接单元。与结构更复杂的榄香酸类相比，本发明的化合物结构更简单，易于合成且更有效。
• GALLOTANNINS AND ELLIGITANNINS AS REGULATORS OF CYTOKINE RELEASE
  申请人：FELDMAN KENNETH S.

  公开号：US20080070850A1

  公开（公告）日：2008-03-20

  A means and method for increasing or inhibiting the secretion of cytokines using gallotannins and ellagitannins is described. The preferred cytokine release inhibiting compounds are dimeric gallotannins having a linker molecule that misaligns the carbohydrate cores of the compounds. The preferred cytokine release promoting gallotannins and ellagitannins include a diaryl ether linker unit. In comparison to the more structurally complex ellagitannins, the compounds of this invention are structurally simpler, easier to synthesize, and more potent.

  本发明描述了使用没食子酸单宁和榄皮酸单宁增加或抑制细胞因子分泌的方法和手段。优选的细胞因子释放抑制化合物是具有链接分子的二聚没食子酸单宁，该链接分子使化合物的碳水化合物核心错位。优选的细胞因子释放促进没食子酸单宁和榄皮酸单宁包括一个二芳基醚链接单元。与结构更为复杂的榄皮酸单宁相比，本发明的化合物结构更简单，更易于合成，且更具有活性。