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(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-[(6-Deoxy-2,3,4-tri-O-methyl-a-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecin-7,15-dione; (-)-Spinosyn A; A 83543A; Lepicidin A; Spinosad A; Spinosyn A

中文名称
——
中文别名
——
英文名称
(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-[(6-Deoxy-2,3,4-tri-O-methyl-a-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecin-7,15-dione; (-)-Spinosyn A; A 83543A; Lepicidin A; Spinosad A; Spinosyn A
英文别名
(2S,5S,7R,9R,10S,14R,15S,19S)-15-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-19-ethyl-14-methyl-7-[(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetracyclo[10.10.0.02,10.05,9]docosa-3,11-diene-13,21-dione
(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-[(6-Deoxy-2,3,4-tri-O-methyl-a-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecin-7,15-dione; (-)-Spinosyn A; A 83543A; Lepicidin A; Spinosad A; Spinosyn A化学式
CAS
——
化学式
C41H65NO10
mdl
——
分子量
732.0
InChiKey
SRJQTHAZUNRMPR-MGGCLMNKSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.9
  • 重原子数:
    52
  • 可旋转键数:
    9
  • 环数:
    6.0
  • sp3杂化的碳原子比例:
    0.85
  • 拓扑面积:
    111
  • 氢给体数:
    0
  • 氢受体数:
    11

ADMET

毒理性
  • 致癌性证据
癌症分类:不太可能对人类致癌 /斯皮诺萨德/
Cancer Classification: Not Likely to be Carcinogenic to Humans /Spinosad/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
  • 解毒与急救
基本治疗:建立专利气道。如有必要,进行吸痰。观察呼吸不足的迹象,并在需要时辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿,并在必要时进行治疗……。监测休克,并在必要时进行治疗……。预期癫痫发作,并在必要时进行治疗……。对于眼睛污染,立即用水冲洗眼睛。在运输过程中用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于误食,如果患者能吞咽、有强烈的干呕反射且不流口水,则用水冲洗口腔,并给予5毫升/千克,最多200毫升的水进行稀释……。在去污后,用干性无菌敷料覆盖皮肤烧伤……。/毒药A和B/
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
  • 解毒与急救
高级治疗:对于昏迷、严重肺水肿或呼吸停止的患者,考虑进行口咽或鼻咽插管以控制气道。使用带有气囊面罩的装置进行正压通气技术可能有益。监测心率和必要时治疗心律失常。 ... 开始静脉输液,使用5%葡萄糖盐水/生理盐水: "保持开放",最低流速/。如果出现低血容量的迹象,使用乳酸钠林格氏液。注意液体过载的迹象。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压,谨慎给予液体。注意液体过载的迹象。使用地西泮(安定)治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。 /毒药A和B/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
  • 非人类毒性摘录
实验室动物:急性暴露/家兔眼中轻微结膜炎/。/90.4% 螨虫酯技术/
/LABORATORY ANIMALS: Acute Exposure/ Slight conjunctival irritation /in the eyes of rabbits/. /90.4% Spinosad technical/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
  • 非人类毒性摘录
实验室动物:急性暴露/家兔皮肤刺激性试验中出现轻微暂时性红斑和水肿;豚鼠皮肤致敏试验中未见皮肤致敏性/90.4% 螺旋霉素技术/评论文章;研究信息不完整/
/LABORATORY ANIMALS: Acute Exposure/ Slight transient erythema and edema in rabbit dermal irritation test; not a dermal sensitizer in guinea pigs/90.4% Spinosad technical/Review article; study information incomplete/
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
... 奶牛在28天内以相当于0、1、3和10微克/克的剂量饲喂了spinosad。母鸡在42天内以相当于0、0.1、0.3、1和5微克/克的剂量饲喂了spinosad。通过高效液相色谱和/或免疫分析方法分析了牛奶、鸡蛋和组织样本。Spinosad残留物出现在所有样本类型中,但在鸡蛋、脱脂牛奶和瘦肉中最低,在脂肪中最高。/Spinosad/
... Dairy cows were dosed for 28 days with spinosad at rates equivalent to 0, 1, 3, and 10 ug/g in the diet. Chicken hens were dosed for 42 days with spinosad at rates equivalent to 0, 0.1, 0.3, 1, and 5 ug/g in the diet. Milk, eggs, and tissue samples were analyzed by high-performance liquid chromatography and/or immunoassay methods. Spinosad residues occurred in all of the sample types but were lowest in eggs, skim milk, and lean meat and were highest in the fat. /Spinosad/
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
Spinosad 吸收迅速且广泛代谢。在大鼠口服给药后,Spinosyn A 和 Spinosyn D 的生物利用度、排泄途径或速率或代谢方面没有显著差异。此外,重复给药也不会影响排泄途径和速率。
Spinosad is rapidly absorbed and extensively metabolized. There were no major differences in the bioavailability, routes or rates of excretion, or metabolism of Spinosyn A and Spinosyn D following oral administration in rats. In addition, the routes and rates of excretion were not affected by repeated administration.
来源:Hazardous Substances Data Bank (HSDB)