(R)-3-methoxy-2,2-dimethylcyclopentanone | 1005773-86-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-3-methoxy-2,2-dimethylcyclopentanone
• 英文别名: (3R)-3-methoxy-2,2-dimethylcyclopentan-1-one
• CAS: 1005773-86-3
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: GTUHSENBKGQKBW-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-3-methoxy-2,2-dimethylcyclopentanone 在 间氯过氧苯甲酸 、 scandium tris(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以99%的产率得到(R)-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-one
  参考文献：
  名称：

  Alternative and Expedient Asymmetric Syntheses of l-(+)-Noviose

  摘要：

  L-(+)-Noviose, the sugar component of the antibiotic novobiocin, was synthesized from readily available non-carbohydrate starting materials relying on stoichiometric and asymmetric processes by two independent methods, comprising six and nine steps, in 27 and 20% overall yields, respectively.

  DOI：

  10.1021/ol702655c
• 作为产物：
  描述：

  (R)-3-hydroxy-2,2-dimethylcyclopentanone 、 碘甲烷 在 silver(l) oxide 作用下， 反应 120.0h， 以88%的产率得到(R)-3-methoxy-2,2-dimethylcyclopentanone
  参考文献：
  名称：

  Alternative and Expedient Asymmetric Syntheses of l-(+)-Noviose

  摘要：

  L-(+)-Noviose, the sugar component of the antibiotic novobiocin, was synthesized from readily available non-carbohydrate starting materials relying on stoichiometric and asymmetric processes by two independent methods, comprising six and nine steps, in 27 and 20% overall yields, respectively.

  DOI：

  10.1021/ol702655c

文献信息

• Alternative and Expedient Asymmetric Syntheses of <scp>l</scp>-(+)-Noviose
  作者：Stephen Hanessian、Luciana Auzzas

  DOI：10.1021/ol702655c

  日期：2008.1.1

  L-(+)-Noviose, the sugar component of the antibiotic novobiocin, was synthesized from readily available non-carbohydrate starting materials relying on stoichiometric and asymmetric processes by two independent methods, comprising six and nine steps, in 27 and 20% overall yields, respectively.