(R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol | 1007107-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol
• 英文别名: (5R)-2-(2-phenylethynyl)-5,6,7,8-tetrahydroquinolin-5-ol
• CAS: 1007107-73-4
• 化学式: C₁₇H₁₅NO
• 分子量: 249.312
• InChiKey: VUDNTKZUIAXLLZ-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one 在 sodium tetrahydroborate 作用下， 以 异丙醇 为溶剂， 反应 5.0h， 以46%的产率得到(R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol
  参考文献：
  名称：

  Positive and Negative Modulation of Group I Metabotropic Glutamate Receptors

  摘要：

  A discriminating pharmacophore model for noncompetitive metabotropic glutamate receptor antagonists of subtype 1 (mGluR1) was developed that facilitated the discovery of moderately active mGluR1 antagonists. One scaffold was selected for the design of several focused libraries where different substitution patterns were introduced. This approach facilitated the discovery of potent mGluR1 antagonists, as well as positive and negative mGluR5 modulators, because both receptor subtypes share similar binding pockets. For mGluR1 antagonists, a homology model of the mGlu1 receptor was established and a putative binding mode within the receptor's transmembrane domain was visualized.

  DOI：

  10.1021/jm0611298