[3-Oxo-3-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propylamino]propyl] nitrate | 1011297-20-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [3-Oxo-3-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propylamino]propyl] nitrate
• CAS: 1011297-20-3
• 化学式: C₁₉H₂₄N₄O₄
• 分子量: 372.424
• InChiKey: WULXLMMPBPDQLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  9-[N^γ-(3'-bromopropanoyl)-γ-aminopropylamino]-1,2,3,4-tetrahydroacridine 在 silver nitrate 作用下， 以 乙腈 为溶剂， 反应 18.0h， 以56%的产率得到[3-Oxo-3-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propylamino]propyl] nitrate
  参考文献：
  名称：

  Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates

  摘要：

  In search of safer anti-Alzheimer drugs, 14 NO-donor-tacrine hybrids (1-14) were synthesized and evaluated for their ability to inhibit cholinesterases and for vasorelaxation effects. Compounds 1-13 showed good cholinesterases inhibitory activities in vitro, while 14, particularly, was highly selective, preferring butyrylcholinesterase rather than acetylcholinesterase. Four selected compounds (1, 9, 11, and 14) moderately relaxed the porcine pulmonary arteries in organ bath. In the hepatotoxicity study, significant hepatotoxicity was caused by tacrine but not by 9.

  DOI：

  10.1021/jm701491k

文献信息

• Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates
  作者：Lei Fang、Dorothea Appenroth、Michael Decker、Michael Kiehntopf、Carolin Roegler、Thomas Deufel、Christian Fleck、Sixun Peng、Yihua Zhang、Jochen Lehmann

  DOI：10.1021/jm701491k

  日期：2008.2.1

  In search of safer anti-Alzheimer drugs, 14 NO-donor-tacrine hybrids (1-14) were synthesized and evaluated for their ability to inhibit cholinesterases and for vasorelaxation effects. Compounds 1-13 showed good cholinesterases inhibitory activities in vitro, while 14, particularly, was highly selective, preferring butyrylcholinesterase rather than acetylcholinesterase. Four selected compounds (1, 9, 11, and 14) moderately relaxed the porcine pulmonary arteries in organ bath. In the hepatotoxicity study, significant hepatotoxicity was caused by tacrine but not by 9.