(E)-1-phenyl-3-[4-[5-(1-piperidyl)pentylsulfanyl]phenyl]prop-2-en-1-one | 955924-83-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-1-phenyl-3-[4-[5-(1-piperidyl)pentylsulfanyl]phenyl]prop-2-en-1-one
• 英文别名: (E)-1-phenyl-3-[4-(5-piperidin-1-ylpentylsulfanyl)phenyl]prop-2-en-1-one
• CAS: 955924-83-1
• 化学式: C₂₅H₃₁NOS
• 分子量: 393.593
• InChiKey: IVSMURHPENQJJU-SAPNQHFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 (E)-3-[4-(5-bromopentylsulfanyl)phenyl]-1-phenylprop-2-en-1-one 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 (E)-1-phenyl-3-[4-[5-(1-piperidyl)pentylsulfanyl]phenyl]prop-2-en-1-one
  参考文献：
  名称：

  Synthesis, physicochemical properties and antimicrobial evaluation of new (E)-chalcones

  摘要：

  In a wide search program towards new and efficient antimicrobial agents, a series of 40 substituted chalcones have been synthesized and tested for their in vitro antibacterial and antifungal activities. The structures of these compounds have been investigated by nuclear magnetic resonance spectroscopy and mass spectrometry. Among the (E)-4-aminoalkylthiochalcones and (E)-4-aminoalkoxychalcones tested, compounds 7, 10, 11, 30 and 31 have exhibited good antibacterial property against Staphylococcus aureus, Enterococcus faecalis and Bacillus subtilis. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.05.006

文献信息

• Synthesis, physicochemical properties and antimicrobial evaluation of new (E)-chalcones
  作者：Z. Nowakowska、B. Kędzia、G. Schroeder

  DOI：10.1016/j.ejmech.2007.05.006

  日期：2008.4

  In a wide search program towards new and efficient antimicrobial agents, a series of 40 substituted chalcones have been synthesized and tested for their in vitro antibacterial and antifungal activities. The structures of these compounds have been investigated by nuclear magnetic resonance spectroscopy and mass spectrometry. Among the (E)-4-aminoalkylthiochalcones and (E)-4-aminoalkoxychalcones tested, compounds 7, 10, 11, 30 and 31 have exhibited good antibacterial property against Staphylococcus aureus, Enterococcus faecalis and Bacillus subtilis. (c) 2007 Elsevier Masson SAS. All rights reserved.